EVALUATION OF THE EFFECTIVENESS OF THE USE OF A SYNBIOTIC COMPLEX CONTAINING STREPTOCOCCUS THERMOPHILUS LYSATE AMONG ADOLESCENTS WITH A HIGH RISK OF CARIES-Reference-Cited by-同舟云学术

EVALUATION OF THE EFFECTIVENESS OF THE USE OF A SYNBIOTIC COMPLEX CONTAINING STREPTOCOCCUS THERMOPHILUS LYSATE AMONG ADOLESCENTS WITH A HIGH RISK OF CARIES

Published:2023-08-21 Issue:2 Volume:19 Page:85-90
ISSN:2077-7566
Container-title:Actual problems in dentistry
language:en
Short-container-title:

Author:

Kisel'nikova Larisa¹^ORCID,Sadovskiy Vladimir²^ORCID,Alekseeva Irina³^ORCID,Ostrovskaya Irina⁴^ORCID,Ostrovskaya Yulia⁵^ORCID

Affiliation:

1. Moscow State Medical-Stomatological University. named after E.I. Evdokimova

2. National Institute for Research and Adaptation of Marketing Strategies

3. Moscow State University of Medicine and Dentistry

4. Moscow State Medical and Dental University named after A.I.Evdokimov

5. Moskovskiy gosudarstvennyy mediko-stomatologicheskiy universitet im. A. I. Evdokimova

Abstract

Relevance. Assessment of the risk of occurrence, prevention and treatment of caries and gingivitis in adolescents. Objective. To evaluate the effectiveness of the use of an oral rinse containing Streptococcus thermophilus lysate in adolescents with a high risk of caries. Materials and methods. The examined 25 adolescents aged 11 to 18 years used a mouthwash "Dentabalance ®" synbiotic complex for a month. The effectiveness of preventive and therapeutic measures was evaluated before and after a month of using the rinse aid by the oral hygiene index OHI-S, periodontal index PMA and indicators of mixed saliva by determining the activity of enzymes by spectrophotometric method: aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (alkaline phosphatase) in IU/l; by gas-liquid chromatography, the amount of acetic, propionic and butyric acids in mol/l. Results. High index values were observed in adolescents with a high risk of caries of permanent teeth: CPU (6,7), OHI-S (2,43 ± 0,07), PMA (62,1 ± 3,0%). In the mixed saliva, increased activity of enzymes was detected, the values of which were AST — 42.0 ± 8.1IU/l; LDH — 490 ± 51.2 IU/l; SCHF — 30.6 ± 1.94IU /l, the indicators of acetic and propionic acids were 2.38 ± 0.48 mol/l and 0.25 ± 0.03 mol/l, respectively, and the content of butyric acid was not determined. After the use of a mouthwash containing Streptococcus thermophilus lysate by adolescents, the indicators of the hygiene index OHI-S decreased statistically significantly (p < 0.05) by 54.1% and the values of the PMA index by 53.3%; in mixed saliva, a decrease in the activity of AST was determined by 3.5 times, LDH by 4.7 times, alkaline phosphatase by 1.4 times, and also, the number of short-chain organic acids — acetic by 4.7 times and propionic by 1.4 times. Conclusions. The Dentabalance ® mouthwash is a synbiotic complex containing Streptococcus thermophilus lysate, has an anti-carious and anti-inflammatory effect, which allows it to be recommended for use by adolescents with a high risk of caries and gingivitis.Relevance: Due to the high prevalence of caries and inflammatory lesions of periodontal tissues in adolescents, the assessment of the risk of occurrence, prevention and treatment of these diseases remains relevant.

Publisher

TIRAZH Publishing House

Subject

General Medicine

Reference16 articles.

1. Кисельникова Л.П., Ермуханова Г.Т., Леус Е.С., Бояркина Е.С., Зуева Т.Е. Изучение взаимосвязей кариеса зубов и индикаторов риска, общих для подростков Беларуси, Казахстана и России. Стоматология детского возраста и профилактика. 2018;17(1):4-10. [L.P Kiselnikova, G.T Ermukhanova, E.S. Leus, E.S Boyarkina, T.E Zueva. Studying the interrelationships of dental caries and risk indicators common to adolescents in Belarus, Kazakhstan and Russia. Pediatric dentistry and prevention. 2018;17(1):4-10. (In Russ.)]. DOI 10.25636/PMP.3.2018.1.1. – EDN UQDZLO., Kisel'nikova L.P., Ermuhanova G.T., Leus E.S., Boyarkina E.S., Zueva T.E. Izuchenie vzaimosvyazey kariesa zubov i indikatorov riska, obschih dlya podrostkov Belarusi, Kazahstana i Rossii. Stomatologiya detskogo vozrasta i profilaktika. 2018;17(1):4-10. [L.P Kiselnikova, G.T Ermukhanova, E.S. Leus, E.S Boyarkina, T.E Zueva. Studying the interrelationships of dental caries and risk indicators common to adolescents in Belarus, Kazakhstan and Russia. Pediatric dentistry and prevention. 2018;17(1):4-10. (In Russ.)]. DOI 10.25636/PMP.3.2018.1.1. – EDN UQDZLO.

2. Екимов Е.В., Сметанин А.А. Повышение эффективности профилактических мероприятий кариеса зубов в детском возрасте с использованием реминерализирующих средств (обзор литературы). Стоматология детского возраста и профилактика. 2018;18(30):18-22.[E.V. Ekimov, A.A. Smetanin. Increase of preventive care effectiveness of childhood dentalcaries with the use of remineralizing agents (theliterary review). Pediatric dentistry and dentalprophylaxis. 2018;18(30):1822. (In Russ.)]. https://doi.org/10.25636/PMP.3.2018.3.3, Ekimov E.V., Smetanin A.A. Povyshenie effektivnosti profilakticheskih meropriyatiy kariesa zubov v detskom vozraste s ispol'zovaniem remineraliziruyuschih sredstv (obzor literatury). Stomatologiya detskogo vozrasta i profilaktika. 2018;18(30):18-22.[E.V. Ekimov, A.A. Smetanin. Increase of preventive care effectiveness of childhood dentalcaries with the use of remineralizing agents (theliterary review). Pediatric dentistry and dentalprophylaxis. 2018;18(30):1822. (In Russ.)]. https://doi.org/10.25636/PMP.3.2018.3.3

3. Улитовский С.Б., Алексеева Е.С., Леонтьев А.А., Шевцов А.В. Оценка влияния индексных показателей и гигиенических знаний на стоматологический статус подростков в период ортодонтического лечения брекет-системами. Стоматология детского возраста и профилактика. 2020;20(2):143-149. [S.B. Ulitovsky, E.S.Alekseeva, A.A.Leontiev, A.V. Shevtsov. Assessment of the influence of index indicators and hygienic knowledge on the dental status of adolescents during orthodontic treatment with braces. Pediatric dentistry and prevention. 2020;20(2):143-149. (In Russ.)]. https://doi.org/10.33925/1683-3031-2020-20-2-143-149, Ulitovskiy S.B., Alekseeva E.S., Leont'ev A.A., Shevcov A.V. Ocenka vliyaniya indeksnyh pokazateley i gigienicheskih znaniy na stomatologicheskiy status podrostkov v period ortodonticheskogo lecheniya breket-sistemami. Stomatologiya detskogo vozrasta i profilaktika. 2020;20(2):143-149. [S.B. Ulitovsky, E.S.Alekseeva, A.A.Leontiev, A.V. Shevtsov. Assessment of the influence of index indicators and hygienic knowledge on the dental status of adolescents during orthodontic treatment with braces. Pediatric dentistry and prevention. 2020;20(2):143-149. (In Russ.)]. https://doi.org/10.33925/1683-3031-2020-20-2-143-149

4. Bowen W.H, Burne R.A, Wu H, Koo H. Oral biofilms: pathogens, matrix, and polymicrobial interactions in microenvironments // Trends Microbiol. – 2018;26:229-242. doi: 10.1016/j.tim.2017.09.008., Bowen W.H, Burne R.A, Wu H, Koo H. Oral biofilms: pathogens, matrix, and polymicrobial interactions in microenvironments // Trends Microbiol. – 2018;26:229-242. doi: 10.1016/j.tim.2017.09.008.

5. Ильина Т.С., Романова Ю.М. Бактериальные биопленки: роль в хронических инфекционных процессах и поиск средств борьбы с ними. Молекулярная генетика, микробиология и вирусология. 2021;39(2):14-24. [T.S Ilina., Yu.M. Romanova. Bacterial biofilms: their role in chronic infectious processes and the search for means to combat them. Molecular genetics, microbiology and virology. 2021;39(2):14-24. (In Russ.)]. https://doi.org/10.17116/molgen20213902114, Il'ina T.S., Romanova Yu.M. Bakterial'nye bioplenki: rol' v hronicheskih infekcionnyh processah i poisk sredstv bor'by s nimi. Molekulyarnaya genetika, mikrobiologiya i virusologiya. 2021;39(2):14-24. [T.S Ilina., Yu.M. Romanova. Bacterial biofilms: their role in chronic infectious processes and the search for means to combat them. Molecular genetics, microbiology and virology. 2021;39(2):14-24. (In Russ.)]. https://doi.org/10.17116/molgen20213902114