THE ROLE OF ZINC IN THE TREATMENT OF DESQUAMATIVE GLOSSITIS

Author:

Uspenskaya Ol'ga1,Kazarina Natalya2,Shaykhutdinova Alina2,Magomedova Khadizhat2

Affiliation:

1. Volga Research Medical University

2. Privolzhsky Research Medical University

Abstract

Desquamative glossitis is a disease characterized by an unclear etiology, torpidity of the course, recurrence-proneness. The mechanism underlying the disease development is cellular kinetics disorders. The essential micronutrient zinc is an apoptotic inhibitor in various cellular systems, including the epithelium. Methodology. The study involved 33 patients with desquamative glossitis. In all cases, traditional local treatment with keratoplastics was prescribed, supplemented with the appointment of zinc-containing toothpaste (contains zinc lactate) and an oral preparation containing zinc oxide (2 mg in one tablet). The determination of zinc in the oral fluid was carried out using a method of mass spectrometry with an ion source in the form of inductively coupled plasma (ICP-MS). Units of measurement mmol/l. Results. When prescribing zinc preparations of general and/or local action, the concentration of zinc in the oral fluid increases in each group (*p < 0.05,**p < 0.001). The rate of epithelization of lesions with desquamative glossitis is higher when taking zinc preparations orally, while the maximum rate of epithelization is observed with simultaneous local and general use of zinc-containing agents (p < 0.05). Conclusion. Our study demonstrated the clinical effectiveness of zinc-containing drugs in the treatment of desquamative glossitis, which is confirmed by an increase in the rate of epithelialization and a decrease in the area of lesions when they are used with the registration of an increase in the level of zinc in the oral fluid.

Publisher

TIRAZH Publishing House

Subject

General Medicine

Reference16 articles.

1. Легонькова Т.И., Штыкова О.Н., Войтенкова О.В., Степина Т.Г. Клиническое значение цинка: результаты проспективного наблюдения за детьми в течение 14 лет. МС. 2018;11. [T.I. Legonkova, O.N. Shtykova, O.V. Voitenkova, T.G. Stepina. Clinical Significance of Zinc: Results of the 14-year prospective study of children. Мedical Сouncil. 2018;11. (In Russ.)]. https://cyberleninka.ru/article/n/klinicheskoe-znachenie-tsinka-rezultaty-prospektivnogo-nablyudeniya-za-detmi-v-techenie-14-let, Legon'kova T.I., Shtykova O.N., Voytenkova O.V., Stepina T.G. Klinicheskoe znachenie cinka: rezul'taty prospektivnogo nablyudeniya za det'mi v techenie 14 let. MS. 2018;11. [T.I. Legonkova, O.N. Shtykova, O.V. Voitenkova, T.G. Stepina. Clinical Significance of Zinc: Results of the 14-year prospective study of children. Medical Souncil. 2018;11. (In Russ.)]. https://cyberleninka.ru/article/n/klinicheskoe-znachenie-tsinka-rezultaty-prospektivnogo-nablyudeniya-za-detmi-v-techenie-14-let

2. Махсумова С.С, Досмухаммедов Э.Х., Хасанов Ф., Адылова Ф.А. Профилактика кариеса: влияние цинка и фтора на резистентность эмали. Вестник науки и образования. 2021;13-2:116. [S.S. Makhsumova, E.Kh. Dosmukhammedov, F. Khasanov, F.A. Adylova. Prevention of caries: the effect of Zinc and Fluoride on enamel resistance. Scientific Journal. 2021;13-2:116. (In Russ.)]. https://cyberleninka.ru/article/n/profilaktika-kariesa-vliyanie-tsinka-i-ftora-na-rezistentnost-emali, Mahsumova S.S, Dosmuhammedov E.H., Hasanov F., Adylova F.A. Profilaktika kariesa: vliyanie cinka i ftora na rezistentnost' emali. Vestnik nauki i obrazovaniya. 2021;13-2:116. [S.S. Makhsumova, E.Kh. Dosmukhammedov, F. Khasanov, F.A. Adylova. Prevention of caries: the effect of Zinc and Fluoride on enamel resistance. Scientific Journal. 2021;13-2:116. (In Russ.)]. https://cyberleninka.ru/article/n/profilaktika-kariesa-vliyanie-tsinka-i-ftora-na-rezistentnost-emali

3. Мухина Ю.Г., Ключников Ю.Г., Нетребенко О.К. и др. Клиническое значение нарушений метаболизма цинка. Авторские лекции по педиатрии. 2005. [Yu.G. Mukhina, S.O. Kliuchnikov, O.K. Netrebenko et al. Clinical significance of zinc metabolism disorders. Author's lectures on pediatrics. Moscow. 2005. (In Russ.)]. http://medvuz.com/med1808/t3/22.php, Muhina Yu.G., Klyuchnikov Yu.G., Netrebenko O.K. i dr. Klinicheskoe znachenie narusheniy metabolizma cinka. Avtorskie lekcii po pediatrii. 2005. [Yu.G. Mukhina, S.O. Kliuchnikov, O.K. Netrebenko et al. Clinical significance of zinc metabolism disorders. Author's lectures on pediatrics. Moscow. 2005. (In Russ.)]. http://medvuz.com/med1808/t3/22.php

4. Новикова В.П., Хавкин А.И. Дефицит цинка и микробиота кишечника. Вопросы практической педиатрии. 2021;16(3):92-98. [V.P. Novikova, A.I. Havkin. Zinc deficiency and intestinal microbiota. Clinical Practice in Pediatrics. 2021;16(3):92-98. (In Russ.)]. DOI:10.20953/1817-7646-2021-3-92-98, Novikova V.P., Havkin A.I. Deficit cinka i mikrobiota kishechnika. Voprosy prakticheskoy pediatrii. 2021;16(3):92-98. [V.P. Novikova, A.I. Havkin. Zinc deficiency and intestinal microbiota. Clinical Practice in Pediatrics. 2021;16(3):92-98. (In Russ.)]. DOI:10.20953/1817-7646-2021-3-92-98

5. Панюкова С.В., Пирузян А.Л., Корсунская И.М. Себорейный дерматит: как помочь пациенту. Consilium Medicum. 2020;22(7):46-48. [S.V. Paniukova, A.L. Piruzyan, I.M. Korsunskaya. Seborrheic dermatitis: how to help the patient. Consilium Medicum. 2020;22(7):46-48. (In Russ.)]. DOI: 10.26442/20751753.2020.7.200314, Panyukova S.V., Piruzyan A.L., Korsunskaya I.M. Seboreynyy dermatit: kak pomoch' pacientu. Consilium Medicum. 2020;22(7):46-48. [S.V. Paniukova, A.L. Piruzyan, I.M. Korsunskaya. Seborrheic dermatitis: how to help the patient. Consilium Medicum. 2020;22(7):46-48. (In Russ.)]. DOI: 10.26442/20751753.2020.7.200314

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3