EXPERIMENTAL SUBSTANTIATION OF PARODONTROTECTOR EFFICIENCY OF THE COMPLEX OF DRUGS IN RATS WITH TYPE 2 DIABETES DURING ORTHODONTIC TEETH RELOCATION-Reference-Cited by-同舟云学术

EXPERIMENTAL SUBSTANTIATION OF PARODONTROTECTOR EFFICIENCY OF THE COMPLEX OF DRUGS IN RATS WITH TYPE 2 DIABETES DURING ORTHODONTIC TEETH RELOCATION

Published:2020-11-05 Issue:3 Volume:16 Page:46-52
ISSN:2077-7566
Container-title:Actual problems in dentistry
language:en
Short-container-title:

Author:

Dem'yanenko Svetlana¹,Morozova Marina²,Morozov Andrey³,Denga Anastasiya⁴,Makarenko Olga⁴

Affiliation:

1. Crimea State Medical University named after S.I.Georgievsky

2. Medical Academy named after S.I.

3. Medical Academy named after S.I. Georgievsky

4. Institute of Dentistry and Maxillofacial Surgery of the National Academy of Medical Sciences of Ukraine

Abstract

Introduction. Pathological changes in the periodontium in people with diabetes mellitus, according to some data, are aggravated after orthodontic intervention, which dictates the need to carry out preventive measures, the effectiveness of which will determine the quality of orthodontic treatment. The aim of this study was to study the periodontal protective effect of two domestic antidisbiotic drugs containing plant extracts, vitamins, calcium and phosphorus salts. Methodology. The experiments were carried out on white Wistar rats, divided into 5 groups. The gums and periodontal bone tissue were isolated. The activity of urease, lysozyme and the content of hyaluronic acid was determined in the gingival homogenate, and the degree of dysbiosis was calculated. In the homogenate of the periodontal bone tissue, the activity of alkaline and acid phosphatases was determined, the mineralization index and the degree of mineralization, as well as the content of calcium and protein, were calculated. Results. The obtained results of our study have convincingly proved the pronounced periodontal protection efficacy of antidisbiotic drugs for oral applications of the plates "CM-2" and the drug Enoant polyphenols. The proposed therapeutic and prophylactic complex inhibits inflammation, destruction of bone tissue and the development of dysbiosis, along with the manifestation of pronounced adaptogenic, antimicrobial and periodontal protective effects in experimental animals against the background of the development of type 2 diabetes mellitus and orthodontic tooth movement. Conclusion. The proposed therapeutic and prophylactic complex inhibits inflammation, destruction of bone tissue and the development of dysbiosis in experimental animals against the background of the development of type 2 diabetes mellitus and orthodontic tooth movement. The obtained results of the experimental study serve as the basis for the recommendation of the investigated complex, including the local application of plates with herbal extracts, vitamins, calcium and microelements, along with the systemic use of grape polyphenol concentrate, in an orthodontic clinic for patients with diabetes mellitus.

Publisher

TIRAZH Publishing House

Reference28 articles.

1. Взаимосвязь инсулинорезистентности и полиморфизмов генов липидного обмена и ренин-ангиотензин-альдостероновой системы : обзор литературы / А. Т. Шаханова, Н. Е. Аукенов, А. У. Нуртазина, Т. Е. Шаханов, Д. К. Кожахметова // Наука и здравоохранение. – 2019. – № 4. – С. 50–59., Shakhanova, A. T., Aukenov, N. E., Nurtazina, A. U., Shakhanov, T. E., Kozhakhmetova, D. K. (2019). Vzaimosvyaz' insulinorezistentnosti i polimorfizmov genov lipidnogo obmena i renin-angiotenzin-al'dosteronovoy sistemy : obzor literatury [The relationship of insulin resistance and polymorphisms of lipid metabolism genes and the renin-angiotensin-aldosterone system : literature review]. Nauka i zdravoohranenie [Science and health care], 4, 50–59. (In Russ.)

2. Кондратьева, Л. В. Инсулинорезистентность при ревматоидном артрите: взаимосвязь с нарушениями липидного обмена и метаболическим синдромом / Л. В. Кондратьева, Т. В. Попкова, Е. Л. Насонов // Научно-практическая ревматология. – 2019. – № 3. – С. 280–283., Kondratieva, L. V., Popkova, T. V., Nasonov, E. L. (2019). Insulinorezistentnost' pri revmatoidnom artrite: vzaimosvyaz' s narusheniyami lipidnogo obmena i metabolicheskim sindromom [Insulin resistance in rheumatoid arthritis: relationship with lipid metabolism disorders and metabolic syndrome]. Nauchno-prakticheskaja revmatologija [Scientific and practical rheumatology], 3, 280–283. (In Russ.)

3. Титова, Ю. Ф. Ремоделирование миокарда и липидный обмен у пациентов с артериальной гипертензией при наличии инсулинорезистентности и сахарном диабете 2 типа / Ю. Ф. Титова // Известия Самарского научного центра РАН. – 2014. – Т. 5, № 4. – С. 1326–1329., Titova, Yu. F. (2014). Remodelirovaniye miokarda i lipidnyy obmen u patsiyentov s arterial'noy gipertenziyey pri nalichii insulinorezistentnosti i sakharnom diabete 2 tipa [Myocardial remodeling and lipid metabolism in patients with arterial hypertension in the presence of insulin resistance and type 2 diabetes]. Izvestija Samarskogo nauchnogo centra RAN [Bulletin of the Samara Scientific Center of the Russian Academy of Sciences], 5, 4, 1326–1329. (In Russ.)

4. Локальный цитокиновый статус пациентов с хронической механической травмой слизистой оболочки рта, страдающих сахарным диабетом 1 типа / И. В. Жаркова, М. Ф. Кабирова, Л. П. Герасимова, Э. Н. Когина // Проблемы стоматологии. – 2018. – № 1. – С. 16–20., Zharkova, I. V., Kabirova, M. F., Gerasimova, L. P., Kogina, E. N. (2018). Lokal'nyy tsitokinovyy status patsiyentov s khronicheskoy mekhanicheskoy travmoy slizistoy obolochki rta, stradayushchikh sakharnym diabetom 1 tipa [Local cytokine status of patients with chronic mechanical trauma of the oral mucosa and type 1 diabetes mellitus]. Problemy stomatologii [Actual problems in dentistry], 1, 16–20. (In Russ.)

5. The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System / G. Daryabor, M. R. Atashzar, D. Kabelitz, S. Meri, K. Kalantar // Front Immunol. – 2020. – Vol. 11. – P. 1582. doi:10.3389/fimmu.2020.01582, Daryabor, G., Atashzar, M. R., Kabelitz, D., Meri, S., Kalantar, K. (2020). The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System. Front Immunol, 11. doi:10.3389/fimmu.2020.01582