STUDY OF VASCULARIZATION AND REPARATIVE REGENERATION OF LAMELLAR BONE TISSUE WITH SIMULATED DEFECTS OF MAXILLA (experimental research)

Abstract

Subject. Regeneration is one of the most relevant problems of medicine and biology. As it was before and as it is now, the field of investigation, which is connected with regeneration exploring, is a range of heated debates. There is a direct correlation between regeneration of bones and local metabolism, mineralization and early vascularization, which supplies nourishment and oxygenation of cell structure of the regenerate. Owing to these factors, the bone has only its mechanic properties. This prerequisite has made a lot of investigators to pay attention for vascular-regeneration complex in zone of forming bone regenerate and its mineralization. Such adverse circumstances like lack of local circulation, substantial fragment diastasis, excessive instability and etc. do not generate or form delayed intermediate callus. It should be highlighted that there are significant successes in solving reparative regeneration and cortical bone vascularization problems. Nevertheless, a number of problems are not still tackled, they regard to vascularization and reparative regeneration lamellar bone tissue, particularly, middle zone of the facial bone. Objectives. The study on the base of the experimental researches, to explore the dynamics of reparative regeneration lamellar bone tissue with simulated different size defects of naso-frontal area of rabbit maxilla. Methodology. Materials of the experiment are comprised of IV series of experiments on 68 adults (from 6 months to a year), both sexes rabbits, of “Chinchilla” breed, weighing from 2.5–3.0 kg. All animals were kept in the vivarium of the experimental sector of Institute of Medical Radiology of the Academy of Medical Sciences of the USSR. The investigations included microangiographic, histological and metering quantity of vessels by laser densitometry. Results. It is noted that vascularization abruptly decreases in remote periods of the observation (180, 365 days) and a tendency in an amount reduction of the regenerate vessels, which the proved by histological researches results. Conclsion. Healing of naso-frontalis area defects with a height of 5 mm and more flows from mostly fibrocartilaginous compound, under unfavorable conditions are not restored by bone regenerate.