Affiliation:
1. Kansas City University of Medicine & Biosciences
2. Kansas City University of Medicine & Biosciences (MO)
Abstract
Ochronosis is a rare disease characterized by skin pigment changes and degenerative arthritis caused by deposition of homogentisic acid in joint cartilage. There are exogenous and endogenous forms of the disease with the endogenous form typically caused by alkaptonuria, or a defect in homogentisic acid oxidase enzyme. In this report we present a previously undocumented case of endogenous ochronosis caused by topical hydroquinone use in a 69-year-old Caucasian male without alkaptonuria.
Publisher
Charter Services New York d/b/a Journal of Orthopaedic Experience and Innovation
Reference8 articles.
1. Robbins and Cotran Pathologic Basis of Disease,2010
2. Knee osteoarthrosis secondary to ochronosis: Clinical case;A.M.S.M. Ferreira;Rev Bras Ortop,2014
3. Exogenous ochronosis and pigmented colloid milium from hydroquinone bleaching creams;G.H. Findlay;Br J Dermatol,1975
4. Ochronosis caused by bleaching creams;P.G. Engasser;J Am Acad Dermatol,1984
5. Exogenous ochronosis After Prolonged Use of Topical Hydroquinone (2%) in a 50-Year-Old Indian Female;V. Gandhi;Indian J Dermatol,2012