Abstract
The main theories of striae pathogenesis are the following: mechanical — an atrophic scar as a result of excessive skin stretching, hormonal — increased expression of genes for receptors of various hormones, and genetic theory — striae as a consequence of congenital structural disorders in the formation of epidermal and dermal structures of the skin. Purpose of the study: to analyze the increased risk of formation of hormone-dependent atrophic scars by studying the polymorphism of the genes for estrogen receptor 1, matrix metalloproteinase type-3, and COL1A1. Material and methods. In order to identify genetic factors of increased risk of striae formation, 20 patients with atrophic scars and 15 healthy patients were examined. The work examined the polymorphism of the COL1A1, ESR1, and MMP-3 genes. Results. Comparative analysis of gene polymorphism in patients with hormone-dependent scars determined a statistically significant difference in the distribution of alleles compared to the control group and showed high values of high-risk TT genotypes for COL1A1 (rs1800012). High values of the mutation / mutation allele CC for ESR1 (rs 2234693) were observed, as well as high values of intermediate risk genotypes 5A / 6A for MMP-3 (rs3025058) were detected. The data obtained can be considered as potential risk factors for the development of atrophic scars of the striae phenotype.
Publisher
PANORAMA Publishing House
Reference8 articles.
1. Striae distensae: a comprehensive review and evidence - based evaluation of prophylaxis and treatment;Al-Himdani;Br J Dermatol,2014
2. Expression of estrogen, androgen, and glucocorticoid receptors in recent striae distensae;Cordeiro;Int J Dermatol,2010
3. 3. McKusick VA. Transverse striae distensae in the lumbar area in father and two sons. Birth Defects Orig Artic Ser. 1971; 7: 260-261.
4. 4. Cordeiro RC, de Moraes AM. Striae Distensae: Physiopathology. Surg Cosmet Dermatol. 2009; 1: 137-140.
5. Topical management of striae distensae (stretch marks): prevention and therapy of striae rubrae and albae;Ud-Din;J Eur Acad Dermatol Venereol,2016