Dynamics of clinical and laboratory indicators in patients with diabetic nephropathy caused by arterial hypertension after complex recovery treatment

Abstract

Abstract. The purpose of the study is to evaluate the dynamics of clinical and laboratory parameters with patients suffering from diabetic nephropathy (DN) caused by arterial hypertension (AH) after using complex rehabilitation treatment. Materials and methods. Open-label, prospective, randomized controlled trial was conducted on 148 patients with DN caused by hypertension, whose average age was 62.4 [52.4; 69.9] years old, the duration of AH — 24.5 [14.3; 36.4], diabetes mellitus (DM) type 2–16.8 [14.7; 19.3] and DN — 6.0 [4.0; 8.7] years. We studied clinical symptoms and laboratory parameters in dynamics (glucose, glycated hemoglobin, albumin, creatinine, their ratio, proteinuria and glomerular filtration rate) with this category of patients which included a control group (49 people) who was prescribed standard medication, a comparison group (48 people) who additionally had Nordic walking (NW), and a main group (51 people) that, in addition, was prescribed magnetic laser therapy (MLT) as part of the complex. Research results. The patients suffering from DN caused by AH showed some data indicating the positive effect of complex restorative therapy (medical standard with the additional use of NW and MLT) on the clinical manifestations of pathology and renal function including the condition of the glomerular filter and the endothelium of renal capillaries. Conclusions. The results of the conducted study allow us to recommend the prescription of complex restorative treatment for patients suffering from DN caused by AH taking into account contraindications to the use of physical methods of therapy.