Pulmonary artery thrombosis as one of the crucial pathonorphological signs of COVID-19: results of 7 autopsies and literature review-Reference-Cited by-同舟云学术

Pulmonary artery thrombosis as one of the crucial pathonorphological signs of COVID-19: results of 7 autopsies and literature review

Published:2020-09-13 Issue:9-10 Volume: Page:26-38
ISSN:2074-0190
Container-title:Hirurg (Surgeon)
language:ru
Short-container-title:

Author:

Porembskaya О. Ya.¹^ORCID,Pashovkina О. V.²^ORCID,Tsaplin S. N.³^ORCID,Schastlivtsev I. V.³^ORCID,Zhuravlev S. V.²,Laberko L. A.⁴^ORCID,Rodoman G. V.⁴^ORCID,Kravchuk V. N.⁵^ORCID,Skvortsov A. E.⁵^ORCID,Sayganov S. A.⁵^ORCID,Lobastov K. V.^ORCID

Affiliation:

1. Mechnikov’s North-Western State Medical University, St-Petersburg, Russia; FSBSI Institute of Experimental Medicine, St-Petersburg, Russia

2. Clinical hospital no.1 of the Presidents Administration of Russian Federation, Moscow, Russia

3. Clinical hospital no.1 of the Presidents Administration of Russian Federation, Moscow, Russia; Pirogov Russian National Research Medical University, Moscow Russia

4. Pirogov Russian National Research Medical University, Moscow Russia; Moscow City Clinical Hospital no.24, Moscow, Russia

5. Mechnikov’s North-Western State Medical University, St-Petersburg, Russia

Abstract

Pulmonary artery thrombosis is one of the crucial mechanisms of severe COVID-19 development. Histological examination reveals widespread microvascular thrombosis in 87 % and large branches pulmonary artery thrombosis in 13 % of deceased patients. Caused by viral and immune cytotoxic effect thrombotic lung vasculopathy appears to be the main trigger of pulmonary artery thrombosis. In this study we examined 7 lungs obtained from patients who died from COVID-19. Thrombotic lung vasculopathy was typical sign of all 7 lungs. Endothelial cell destruction, media fibrinoid necrosis, neutrophil and lymphocytic infiltrates of the arterial wall and perivascular tissues were the basic histological changes in the lung arteries of different diameters. All this fatal changes developed independently of the therapeutic and prophylactic anticoagulation.

Publisher

PANORAMA Publishing House

Subject

General Chemical Engineering

Reference22 articles.

1. Klok F. A., Kruip M., van der Meer N., Arbous M. S., Gommers D., Kant K. M., Kaptein F., van Paassen J., StalsM., Huisman M. V., Endeman H. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020; 191: 145–7. https://doi.org/10.1016/j.thromres.2020.04.013.

2. Chibane S., Gibeau G., Poulin F., Tessier P., Goulet M., Carrier M., Lanthier S. Hyperacute multi-organ thromboembolic storm in COVID-19: a case report. J Thromb Thrombolysis. 2020; 1–4. Advance online publication. https://doi:10.1007/s11239-020-02173-w.

3. Helms J., Tacquard C., Severac, F., Leonard-Lorant I., Ohana M., Delabranche X., Merdji H., Clere-Jehl R.,Schenck M., Fagot Gandet F., Fafi -Kremer S., Castelain V., Schneider F., Grunebaum L., Angles-Cano E., Sattler L., Mertes P. M., Meziani F. CRICS TRIGGERSEP Group (Clinical Research in Intensive Care and Sepsis Trial Group for Global Evaluation and Research in Sepsis). High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study. Intensive Care Med. 2020; 46 (6): 1089–1098. https://doi.org/10.1007/ s00134-020-06062-x.

4. Poissy J., Goutay J., Caplan M., Parmentier E., Duburcq T., Lassalle F., Jeanpierre E., Rauch A., Labreuche J., Susen S. Lille ICU Haemostasis COVID-19 group. Pulmonary Embolism in COVID-19 Patients: Awareness of an Increased Prevalence. Circulation 2020; Circulation, 10.1161/CIRCULATIONAHA.120.047430. Advance online publication. https://doi.org/10.1161/CIRCULATIONAHA.120.047430.

5. Magro C., Mulvey J. J., Berlin D., Nuovo G., Salvatore S., Harp J., Baxter-Stoltzfus A., Laurence J. Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of fi ve cases. Translational research: the journal of laboratory and clinical medicine. 220: 1–13. https://doi.org/10.1016/j.trsl.2020.04.007.

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