Study of early metabolic changes in experimental animals with acute toxic exposure to paracetamol and against the background of correction

Abstract

Paracetamol is one of the most widely used and popular over-the-counter analgesics and antipyretic drugs in the world. The number of registered cases of paracetamol-induced liver intoxication is constantly increasing in the world every year. It seems relevant to study early metabolic disorders in the liver in acute paracetamol intoxication and assess the effectiveness of the timely use of hepatoprotective drugs. The aim of this research is to study metabolic changes in laboratory animals at the early stages of exposure to paracetamol and against the background of correction with oxymethyluracil, ademetionine and mexidol. An experimental study of metabolic changes in laboratory animals under acute exposure to toxic doses of paracetamol and against the background of correction was carried out. Biochemical parameters in the blood serum of laboratory animals were investigated. The obtained results showed that the intake of paracetamol in toxic doses was accompanied by impaired hepatic metabolism at the earliest stages of exposure. With the corrective action of the studied drugs, metabolic disturbances caused by paracetamol intoxication were restored. At the same time, OMU, as well as ademetionine and ethylmethylhydroxypyridine succinate, is able to normalize metabolic changes after the acute toxic effect of paracetamol, and has a pronounced advantage in terms of the protein-synthetic function of hepatocytes.