Features of the manifestation of the COVID-19 epidemic process among employees of a large closed specialized hospital

Abstract

The article presents the features of the epidemiological process of COVID-19 among medical workers of a closed specialized psychiatric hospital. The analysis of the incidence of COVID-19 employees for 2020–2021 was carried out, a laboratory study of blood sera of 310 individuals for class G antibodies to NC (nucleocapsid protein) SARS-CoV-2, twice vaccinated against COVID-19 with the Sputnik V vaccine. The data obtained showed that the true incidence of COVID-19 exceeds the official one. The seasonality of the disease is noted. There were no significant differences in morbidity between men and women. In the age structure of those who were ill and identified with positive IgG antibodies to nucleocapsid (NC)protein, persons aged 40 to 60 and older prevailed — 77.7 %. On a professional basis, the largest proportion of those who were ill and identified with positive results was noted among the middle and junior medical personnel — 50.7 % and 31.6 %, respectively. A laboratory study of the employees’ blood serums showed that IgG to RBD Spike SARS-CoV-2 over 300 IU/ml was detected only in 11.6. At the same time, 88.9 % of them have hybrid immunity formed after vaccination and illness.