Off-label drug use in pediatrics. Literature review-Reference-Cited by-同舟云学术

Off-label drug use in pediatrics. Literature review

Published:2023-05-27 Issue:5 Volume: Page:6-23
ISSN:
Container-title:Glavvrač (Chief Medical Officer)
language:
Short-container-title:Chief Medical Officer

Author:

Badertdinova D. I., ,Zvegintseva A. A.^ORCID,Maksimov M. L.^ORCID, ,

Abstract

At present, due to the accumulated developments in pharmacology and pharmacotherapy, there is a huge variety of drugs for the effective treatment and prevention of many common diseases. This makes it possible to control and manage many pathological conditions. However, each drug should be comprehensively studied, as well as its systemic action, side effects, toxicity, effect when interacting with other drugs, and especially when it accumulates in the body, must be taken into account. There are groups of patients in which clinical trials of drugs are difficult and limited. These are pregnant women, children, and newborns, especially premature ones. A serious deterrent is both severe economic restrictions and ethical issues, such as the protection of the rights of minors and the negative attitude of society towards clinical trials as «experiments on people».

Publisher

PANORAMA Publishing House

Subject

General Medicine,Applied Mathematics,General Engineering,General Medicine,General Materials Science,General Energy,General Medicine,Information Systems and Management,Information Systems,Software,General Medicine,General Medicine

Reference31 articles.

1. 1. Federal Law of the Russian Federation of April 12, 2010 No. 61-FZ «On the circulation of medicines» adopted by the State Duma on March 24, 2010. Approved by the Federation Council on March 31, 2010. (In Russ.)

2. 2. Federal Law of the Russian Federation of November 21, 2011 No. 323-FZ «On the basics of protecting the health of citizens in the Russian Federation» // Rossiyskaya Gazeta, November 23, 2011 No. 263. (In Russ.)

3. 3. Kuzmin S. B., Smirnova M. N. Problema primeneniia lekarstvennykh sredstv v neonatologii [The problem of the use of drugs in neonatology] // Meditsinskoe pravo: teoriia i praktika [Medical Law: Theory and Practice], No. 1. All-Russian scientific and practical conference with international participation «Formation of legal medicine in Russia». (In Russ.)

4. 4. Tarabukina S. M., Dremova N. B. Problema izgotovleniia v bolnichnoi apteke lekarstvennykh preparatov, naznachaemykh «off-label» [The problem of manufacturing medicines prescribed «off-label» in a hospital pharmacy]. Journal Sovremennaia organizatsiia lekarstvennogo obespecheniia [Modern Organization of Drug Supply]. Volume 8, No. 1, 2021. (In Russ.)

5. 5. Kuznetsova E. Iu., Ovchinnikova P. P., Semencheva A. S. Problema primeneniia lekarstvennykh preparatov «off-label» v Rossii [The problem of off-label drug use in Russia] // Mezhdunarodnyi nauchno-issledovatelskii zhurnal [Scientific International Research Journal], 2020. (In Russ.)