Breed-specific SNP markers of beef productivity of cattle of Kazakh White-headed breed

Abstract

One of the most promising modern methods used to identify loci that control quantitative traits of productivity in cattle is the method of Genome-wide association of (GWA), which makes it possible to establish a link between allelic variation in a certain region of the genome and the trait under study. The purpose of the research was to establish breed-specific SNP markers of beef productivity of cattle of Kazakh white-headed breed. The results of the search for breed-specific genetic markers of increased beef productivity for Kazakh White-headed breed based on the data of DNA typing of animals using the GGP Gene Search chip Cattle 150 thousand (Illumina Inc., USA) have been presented. Genotyping data processing for each SNP and each sample was performed using the PLINK 1.9 software package (http://zzz.bwh.harvard.edu/plink/). The search for unique regions of the genome has been carried out by using homozygosity rows (ROH). Homozygosity rows (ROH) have been evaluated for each animal using the QTL database of Cattle PLINK. Seven SNP markers of increased beef productivity have been identified in Kazakh White-headed cattle: allele C (rs109910863) in the histatherin gene (histatherin (HSTN)), allele C (rs110065568) in the myostatin gene (myostatin (MSTN)), allele g (rs110320975) in the histatherin gene (histatherin (HSTN)), allele C ( rs135748641) in the gene of a nucleolar protein interacting with the domain of risk factor MKI67 (nucleolar proteins interacting with FCA domain MKI67 (NIFK), allele g (rs136552787) in the gene of insulin-like factor 6 binding protein (protein, binding insulin-like growth factor 6 (IGFBP6-202)), allele A (rs137243785) in the histatherin gene (histaterin (HSTN-201)), allele A (rs522351439) in the myostatin gene (myostatin (MSTN)).