The choice of excipients in the development of a soft dosage form of phleboprotective action containing a micronized flavonoid fraction-Reference-Cited by-同舟云学术

The choice of excipients in the development of a soft dosage form of phleboprotective action containing a micronized flavonoid fraction

Published:2021-09-15 Issue:5 Volume: Page:25-30
ISSN:
Container-title:Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)
language:ru
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Author:

Maltseva Viktoriya Konstantinovna¹,Stepanova Eleonora Fedorovna²,Kulichenko Evgeniya Olegovna³,Makieva Marina Sergeevna⁴

Affiliation:

1. Department of Pharmaceutical Technology with a course in Medical Biotechnology, Pyatigorsk Medical and Pharmaceutical Institute — a branch of the FSBEI HE Volgograd State Medical University of the Ministry of Health of the Russian Federation, 11, Kalinin ave. Pyatigorsk, Stavropol Region

2. Department of Pharmaceutical Technology with a course of Medical Biotechnology, Pyatigorsk Medical and Pharmaceutical Institute — a branch of the FSBEI HE Volgograd State Medical University of the Ministry of Health of the Russian Federation

3. Department of Microbiology and Immunology with a course in Biological Chemistry, Pyatigorsk Medical and Pharmaceutical Institute — a branch of the FSBEI HE Volgograd State Medical University of the Ministry of Health of the Russian Federation

4. Department of Pharmacy, FSBEI HE North Ossetian State University named after Kosta Levanovich Khetagurov

Abstract

Varicose veins are called one of the diseases of the 21st century, caused by a sedentary lifestyle and genetics. The purpose of this study was the development of ointment compositions containing the micronized flavonoid fraction and the study of the degree of release of the micronized fraction by the flavonoid from the ointment compositions with penetrating components. With the obtained ointment compositions, a complex of biopharmaceutical studies in vitro was carried out: release from ointment compositions by diffusion into a gelatin gel and dialysis through a semipermeable membrane, while the quality indicators of the ointment compositions were established. The conducted in vitro biopharmaceutical studies helped to determine the final composition of the ointment in relation to the auxiliary composition: active ingredient — 2%, PEG 1500:PEG 400 (7:3), propylene glycol — 1%.

Publisher

PANORAMA Publishing House

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