Role of vasopressin signaling in the pathogenesis of diabetic nephropathy

Author:

Margaryan Arus Garikovna1ORCID,Lebedeva Svetlana Anatolievna2ORCID,Lisitsyna Dariya Mikhailovna3ORCID,Sirotkina Polina Igorevna4ORCID,Yakubova Lyudmila Aleksandrovna4ORCID,Tarasov Vadim Vladimirovich1ORCID

Affiliation:

1. Department of Pharmacology, A. P. Nelyubin Institute of Pharmacy, FSAEI HE I. M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University)

2. Department of Pharmacology, A. P. Nelyubin Institute of Pharmacy, FSAEI HE I. M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia

3. enter for Preclinical Research, Institute for Translational Medicine and Biotechnology, Biomedical Science and Technology Park, Sechenov University

4. Faculty «International School «Medicine of the Future», field of training «Medical Biochemistry», FSAEI HE I. M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University)

Abstract

The diabetic kidney disease (also known as diabetic nephropathy) is a major complication of diabetes mellitus and also the most common cause of chronic kidney disease. Elevated plasma levels of vasopressin are consistently observed in patients with either type 1 and type 2 diabetes mellitus and in animal models of diabetes mellitus. A role of enhanced vasopressin signaling in progression of the diabetic nephropathy to chronic kidney disease has been suggested in several epidemiological studies but the underlying pathogenetic mechanisms remain largely unclear and are the subject of current scientific research.

Publisher

PANORAMA Publishing House

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