Taxanes use and neurotoxicity in cancer patients

Author:

Tkachenko E. V.1ORCID,Andreev V. V.2ORCID,Yatsenko A. V.3ORCID,Zheltukhin A. A.4ORCID,Gorbunova K. V.1ORCID,Kondratiev S. V.1ORCID,Klyuge V. A.1ORCID,Brish N. A.1ORCID,Alekseeva Yu. V.1ORCID,Sluzhev M. I.5ORCID,Kasparov B. S.6ORCID,Bondarev N. E.1ORCID,Mimonov E. A.1,Semiglazov V. V.7ORCID,Semiglazova T. Yu.8ORCID,Belyaev A. M.9ORCID

Affiliation:

1. FSBI N.N. Petrov NMRC of Oncology of the Ministry of Health of the Russian Federation

2. FSBI N.N. Petrov NMRC of Oncology of the Ministry of Health of the Russian Federation, FSBEI HE Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation

3. FSBI N.N. Petrov NMRC of Oncology of the Ministry of Health of the Russian Federation; St. Petersburg SBHI Clinical Diagnostic Center

4. SBHI St. Petersburg Clinical Scientifi c and Practical Center of Specialized Types of Medical Care (Oncology)

5. FSBI N.N. Petrov NMRC of Oncology of the Ministry of Health of the Russian Federation; FSBEI HE Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation

6. FSBI N.N. Petrov NMRC of Oncology of the Ministry of Health of the Russian Federation,

7. FSBI N.N. Petrov NMRC of Oncology of the Ministry of Health of the Russian Federation,; FSBEI HE Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation,

8. FSBI N.N. Petrov NMRC of Oncology of the Ministry of Health of the Russian Federation, St. Petersburg; FSBEI HE NorthWestern State Medical University named after I.I. Mechnikov of the Ministry of Health of the Russian Federation, 47 Piskarevsky lane, St. Petersburg

9. FSBI N.N. Petrov NMRC of Oncology of the Ministry of Health of the Russian Federation; FSBEI HE North-Western State Medical University named after I.I. Mechnikov of the Ministry of Health of the Russian Federation

Abstract

The review presents the data on the specifics of mechanism of action, classification, and clinical manifestations of neurotoxicity effect. The most significant features of specific side effects when using taxanes in different treatment regimens, including cumulative doses, are considered. The proven methods of treatment and prevention of neuropathy caused by anticancer drugs are discussed.

Publisher

PANORAMA Publishing House

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