Modern principles of the diagnosis and conservative treatment of Cushing disease

Abstract

Cushing disease is a severe neuro-endocrinological disorder caused by hypersecretion of ACTH from a benign lesion of hypophyseal gland which is clinically represented by symptoms of hypercortisolism. Cushing disease is associated with an increased risk of cardiovascular and metabolic disorders, psychological complications, osteoporosis and infectious diseases which bring about an increased mortality rate. The article considers the clinical and diagnostic aspects of Cushing disease in accordance to the modern international protocols and recommendations along with the modern principles of conservative treatment.