Abstract
Aim: Conduct a meta-analysis of promising studies that compare the pharmacogenetic method of dosing antidepressants and the traditional one. Materials and methods: The search for publications was carried out in the eLibrary systems (www.elibrary.ru), PubMed (www.pubmed.ru), Google scholar, Scopus, Web of Science until 2019. In addition, articles were selected from the literature lists of the found publications. The meta-analysis includes studies that compared the clinical outcomes between the FGT group (experimental) and the control group. The selection of the dose of antidepressants to patients of the experimental group was carried out taking into account the results of genetic testing. These data were not taken into account in the control group. The selected studies were conducted in groups of adult patients who scored on the HDRS scale ≥ 19 points, who were shown to take antidepressants. Results: In 5 articles studied by us, the number of patients who responded to therapy, who were in remission, as well as reducing the number of side effects in the experimental and control groups were compared. The analysis of the data showed the presence of statistically significant differences in the experimental and control groups. In the groups with the pharmacogenetic approach, a large number of patients with remission and responses to therapy were observed, but no effect on the development of the number of side effects was revealed. Conclusion: A meta-analysis of prospective foreign studies has shown the advantage of using a pharmacogenetic approach in prescribing therapy.
Publisher
PANORAMA Publishing House