Personalized approach to the administration of haloperidol in patients with acute alcoholic hallucinatie (literature review)-Reference-Cited by-同舟云学术

Personalized approach to the administration of haloperidol in patients with acute alcoholic hallucinatie (literature review)

Published:2021-07-11 Issue:8 Volume: Page:628-638
ISSN:2074-6822
Container-title:Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery)
language:ru
Short-container-title:

Author:

Parkhomenko Aleksandra Aleksandrovna¹^ORCID,Zastrozhin Mikhail Sergeevich²^ORCID,Skryabin Valentin Yurievich³^ORCID,Savchenko Lyudmila Mikhailovna¹^ORCID,Brun Evgeniy Alekseevich⁴^ORCID,Sychev Dmitriy Alekseevich⁵^ORCID,Yusupov Alisher Akhmedovich⁶^ORCID,Alekseyuk Vladislav Vladimirovich⁷^ORCID,Muradyan Ani Arturovna⁸^ORCID

Affiliation:

1. Department of Narcology, FSBEI FPO Russian Medical Academy of Continuing Professional Education of the Ministry of Health of Russia

2. Laboratory of Genetics and Fundamental Research, SBHI Moscow Scientific and Practical Center of Narcology of the Moscow Healthcare Department, Department of Narcology, FSBEI FPO Russian Medical Academy of Continuing Professional Education of the Ministry of Health of Russia

3. Department, SBHI Moscow Scientific and Practical Center of Narcology of the Moscow Healthcare Department

4. Department of Narcology, FSBEI FPO Russian Medical Academy of Continuing Professional Education of the Ministry of Health of Russia, SBHI Moscow Scientific and Practical Center of Narcology of the Moscow Healthcare Department

5. Russian Academy of Sciences, PhD in Medicine, professor of the Russian Academy of Sciences, rector, head of the Department of Clinical Pharmacology and Therapy, FSBEI FPO Russian Medical Academy of Continuing Professional Education of the Ministry of Health of Russia

6. Department of Emergency Drug Treatment, SBHI Moscow Scientific and Practical Center of Narcology of the Moscow Healthcare Department

7. SBHI Moscow Scientific and Practical Center of Narcology of the Moscow Healthcare Department

8. Department of Narcology, FSBEI FPO Russian Medical Academy of Continuing Professional Education of the Ministry of Health of Russia,

Abstract

To date, it is known that haloperidol is used to treat productive psychopathological symptoms in acute alcoholic hallucinosis, but its use is associated with a high risk of developing undesirable drug reactions (NLR). A number of isoenzymes of the cytochrome P-450 family take part in the metabolism of haloperidol. The biotransformation of haloperidol occurs with the participation of the CYP2D6 isoenzyme encoded by the gene of the same name. The CYP2D6 gene is highly polymorphic, and this polymorphism can lead to a change in the activity of the encoded isoenzyme. Changes in the rate of biotransformation of haloperidol may affect the profile of its effectiveness and safety. This review is aimed at analyzing the information accumulated in the literature on the role of genetic factors in the formation of an individual response to haloperidol therapy in patients with acute alcoholic hallucinosis.

Publisher

PANORAMA Publishing House

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