Hypervitaminosis D: an approach to the choice of doses and therapy regimens

Abstract

Vitamin D is a well-known prohormone, which plays an important role not only in calcium metabolism, but also in cell differentiation and immune modulation. It has a wide therapeutic window. Because of that, toxicity is observed only at relatively high doses. Certain diseases predispose patients to vitamin D toxicity. Mechanisms of this predisposition, together with treatment options and possible vitamin D toxicity outcomes are discussed.