Abstract
Brucellosis is a bacterial disease affecting humans and domestic animals. The pathogenic capacity of Brucella depends on its stealth strategy and ability to replicate within host cells and cause long-lasting infections. The growth of brucellosis in the Russian Federation necessitates the search for new diagnostic approaches and algorithms that allow obtaining valid results in a short time, reducing the risk of chronicity of this pathology. Presently, the diagnosis of brucellosis, due to its pronounced polymorphism, is impossible without objective laboratory confirmation. Search for laboratory predictors is a current trend in modern laboratory medicine.
Publisher
PANORAMA Publishing House
Subject
General Earth and Planetary Sciences,General Environmental Science
Reference10 articles.
1. 1. Metodicheskie ukazaniia «Profilaktika i laboratornaia diagnostika brutselleza liudei» [Guidelines «Prevention and laboratory diagnosis of brucellosis in humans»] (MU 3.1.7.118903). - M.: Ministry of Health of Russia, 2003. - 58 p. (In Russ.)
2. 2. S., El S., Ural S. et al. Evaluation of realtime PCR method for rapid diagnosis of brucellosis with different clinical manifestations // Pol.J. Microbiol. 2009. V. 58 (1). P. 15-19
3. 3. Kulakov Iu. K., Dalgatova A. A., Burgasova O. A., Bakalin V.V. Osobennosti laboratornykh podkhodov v kompleksnoi diagnostike brutselleza u liudei [Features of laboratory approaches in the complex diagnosis of brucellosis in humans] // Epidemiologiia i infektsionnye bolezni [Epidemiology and Infectious Diseases]. 2021. Vol. 26, No. 4. P. 00−00. DOI: https:// doi.org/10.17816/EID108212. (In Russ.)
4. 4. Banai M., Adams L. G., Frey M. et al. The myth of22. Brucella Lforms and possible involvement of Brucella penicillin binding proteins (PBPs) in pathogenicity // Vet. Microbiol. 2002. V. 90. № 1-4. P. 263-279.
5. 5. Mikhailov L. M, Kalinovskii A. I., Balakhonov S.V. Persistentsiia L form brutsell u cheloveka s khronicheskoi formoi brutselleza [Persistence of L forms of Brucella in humans with chronic brucellosis] // Mikrobiologiia [Microbiology]. 2009. No. 5 (1). P. 114, 115. (In Russ.)