Abstract
The purpose of the study: to assess the state of endogenous intoxication, taking into account the study of the sorption capacity of erythrocytes and the level of middle molecule peptides and nitric oxide in patients with acantholytic pemphigus, and identify its role in the course of this dermatosis. Material and methods of the research: clinical, cytological, biochemical, immunological, and statisti cal methods of research were used in patients with acantholytic pemphigus. Results of the study: in patients with acantholytic pemphigus, endogenous intoxication of the body develops, which is expressed by an increase in the sorption capacity of erythrocytes and the level of middle molecule peptides and nitric oxide. Moreover, an increase in the content of endogenous toxins in the blood serum, in particular, middle molecule peptides and nitric oxide, determines the severity of the clinical course in patients with acantholytic pemphigus.
Publisher
PANORAMA Publishing House
Subject
General Earth and Planetary Sciences,General Environmental Science
Reference8 articles.
1. 1. Abaturov A.E. Rol monooksida azota v sisteme nespetsificheskoi zashchity organizma [The role of nitrogen monoxide in the system of nonspecific protection of the organism] // Zdorovie rebenka [Health of the Child]. - 2009. - No. 1 (16). (In Russ.)
2. 2. Abdurashidov A.A. Ekzema bilan khastalangan bemorlarda endogen intoksikatsiiani ҳisobga olib davolashning patogenetik zhiҳatdan asoslanishi. Tib. fan. nomzodi…thesis abstract. Tashkent, 2006. 18b.
3. 3. Gabrielian N.I., Dmitriev A.A., Kulakov G.P. et al. Diagnosticheskaia tsennost opredeleniia srednikh molekul v plazme krovi pri nefrologicheskikh zabolevaniiakh [Diagnostic value of determination of medium molecules in blood plasma in nephrological diseases]. // Klin. med. [Clinical Medicine]. 1981. No. 10. P. 38-42. (In Russ.)
4. 4. Svirshchevskaia E.V., Matushevskaia E.V. Immunopatogenez i lechenie pemfigusa [Immunopathogenesis and treatment of pemphigus]. RMZh [Russian Medical Journal]. 1998;6:6. (In Russ.)
5. Auto-immune manifestations in non-Hodgkin's lymphoma;Jardin;Rev Med Interne,2005