Affiliation:
1. South Ural State Medical University of the Ministry of Health of the Russian Federation
Abstract
The article presents the data from Russian and foreign researchers on the state of humoral and cellular factors of antimicrobial protection of the mucous membrane of the nasal cavity and paranasal sinuses in the pathogenesis of immune disorders in deviated septum. One of the factors affecting the intensity of the inflammatory reaction and the rate of epithelialization of the mucous membrane is a decrease in IL-10 receptor expression, and, as a consequence, a decrease in its endogenous production. In vivo experiments have shown that the reduced expression of genes responsible for the synthesis of interleukin-10 inhibits infiltration of the wound postoperative surface of phagocytes, reducing the expression of CC-chemokines (MCP-1, MIP-1α), their receptors, cytokines, and interleukin-1α. The role of cellular and humoral factors, interreceptor interactions of cells of the respiratory, glandular epithelium, phagocytes, and lymphocytes in pathological conditions of the nasal mucosa and paranasal sinuses was analyzed. The role of immune mechanisms in the development of pathological reactions in deviated septum is shown. The presented review will expand the understanding of the role of antimicrobial factors in the pathogenesis of immune disorders in deviated septum.
Publisher
PANORAMA Publishing House