Oxidative stress and diseases of the cardiovascular system: pathogenetic mechanism and laboratory diagnostics

Abstract

Pathogenesis of oxidative stress is based on an increase in the production offree radicals with reduction in potential of antioxidant protection. The article analyzes results ofresearch on the problem of oxidative stress over the past five years, analyzes thepreviously described mechanisms and causes of free radical damage to cells and tissues, and role of such injuries in hypertension. Modern laboratory diagnostic methods for determining antioxidant status are presented. Role of oxidative stress in the pathogenesis of hypertension is considered. Own data of the author obtained during analysis of laboratory and clinical indicators are presented.