Risk factors of local relapses in patients with breast cancer depending on the properties of the primary tumor

Abstract

Of all a spread of disorders after mastectomy, most frequently we expect about the event of local relapse. The aim – to research the frequency of local relapses in patients with breast carcinoma, considering the subtype properties of the primary tumor. Materials. 6136 patients with breast carcinoma, including 146 patients with LR – main group, and 455 patients without LR – control group. They distributed betting on age, the state of the menstrual function, stage of the disease, histological type of cancer, grade, tumor subtype. Results. In step with the histological structure, ductal carcinoma was commonest. Established the 10-year non-relapse period in main group is longer with Luminal A and Triple-negative subtypes (61 vs 41%) compared to Luminal B and Her-2 / neu type with (3+) amplification (39 % vs 32 % respectively). Conclusions. The stage, histological structure, grade of the tumor does not significantly affect the frequency of local relapses breast cancer patients. The LR is more likely to occur in patients with luminal subtype B, while the littlest frequency of LR occurs with subtype A. Study of the menstrual status of the patient providing local relapses more often arise in women of pre-menopause. Established that the 10-year non-relapse period is that the best in patients with luminal A subtype and TNBC compared to luminal B and HER 2 type with (3+) amplification.