In vivo studies on anti hyperglycemic activity of sericin using rat model

Abstract

Silk protein, sericin was isolated from raw silk fabrication in reeling industry and subsequent process of silk throwing. The majority of it is thrown in the waste water from silk manufacturing. Sericin was used in antibacterial, antioxidant, wound healing, moisturising, and antiaging medications and cosmetics. Limited reports on the use of sericin in the treatment of diabetes prompted the current study on the use of sericin in the control of diabetes in rats. Thus, the present study was aimed to investigate the antihyperglycemic activity of sericin protein using rat model. The results indicated that sericin treated groups showed a noteworthy augment in body weight than the standard drug (Metformin) treatment with diabetic control. Sericin @ 400mg/kg showed 152.6 mg/dl and 141.2 mg/dl on 7th and 21st day of treatment. Similarly, Sericin @ 800mg/kg showed 126.0 mg/dl and 114.0 mg/dl on 7th and 21st day of treatment when compared to control (206.0 mg/dl and 203.6 mg/dl). SGOT of 68.4 and 50.0 units per litre of serum was observed in sericin @ 400 mg/kg and 800mg/kg treated rats when compared to control 138.6 units. SGPT 0f 26.0 and 21.6 units per litre of serum was observed in sericin @ 400 mg/kg and 800mg/kg treated rats when compared to control (75.0 units). Triglycerides of 96.4 and 81. 4 units were observed in sericin @ 400 mg/kg and 800mg/kg treated rats when compared to control (152.8 units).