Affiliation:
1. Oncology Center No. 1 of the City Clinical Hospital named after S. S. Yudin of the Moscow Department of Health; Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia
2. Oncology Center No. 1 of the City Clinical Hospital named after S. S. Yudin of the Moscow Department of Health; I. M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
3. Oncology Center No. 1 of the City Clinical Hospital named after S. S. Yudin of the Moscow Department of Health
Abstract
Positive surgical margin is observed in approximately 10 % of specimens after radical surgery for locally advanced urothelial carcinoma, and is associated with an increased risk of locoregional recurrence, metastases, and death. R+ patients are a heterogeneous group of patients requiring individual treatment approaches. There is no standard of care for R+ patients; acceptable options include observation, removal of residual tumor, postoperative chemotherapy (CT), immunotherapy (IT), radiation therapy (RT), and chemoradiotherapy (CRT). The choice of treatment plan depends on the location and characteristics of the primary tumor, use of neoadjuvant chemotherapy (NACT) before surgery and the response to it, the pathological response, the presence of detectable residual tumor, as well as the potential tolerability of immediate postoperative treatment.
Publisher
Russian Society of Clinical Oncology
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