Distribution of HPV genotypes among women with abnormal cytology results in Alberta, Canada

Author:

Plitt Sabrina S12,Kichuk Ryan3,Geier Sheena4,Smith Trenton2,Roy Felicia5,Severini Alberto56,Charlton Carmen L478

Affiliation:

1. Centre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, Ontario, Canada

2. School of Public Health, University of Alberta, Edmonton, Alberta, Canada

3. Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada

4. Department of Laboratory Medicine, University of Alberta, Edmonton, Alberta, Canada

5. National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

6. Department of Medical Microbiology, Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

7. Public Health Laboratory (ProvLab), Edmonton, Alberta, Canada

8. Li Ka Shing Institute for Virology, Edmonton, Alberta, Canada

Abstract

Background: Persistent infection with a subset of human papillomavirus (HPV) genotypes can cause abnormal cytology and invasive cervical cancer. This study examines the circulating HPV genotype strains in a local population of the province of Alberta (a largely unvaccinated population) to establish baseline frequency of vaccine and non-vaccine genotypes causing abnormal cervical cytology. Method: Remnant liquid-based cytology specimens from the Alberta Cervical Cancer Screening Program (March 2014–January 2016) were examined. Only specimens from women who had a cytology grading of atypical squamous cells of undetermined significance or higher were included. HPV genotype was determined for all samples, and results were stratified by demographics and cytology results. Results: Forty-four unique HPV genotypes were identified from 4,794 samples. Of the 4,241 samples with a genotype identified, the most common genotypes were HPV 16, 18, 31, and 51, with 1,599 (37.7%), 441 (12.2%), 329 (7.8%), and 354 (8.4%), respectively. HPV9 vaccine genotypes made up 73.2% of these genotyped samples. Compared with specimens in which HPV9 vaccine genotypes were not detected, those with a genotype covered by the HPV9 vaccine were from younger women (33 [interquartile range {IQR] 28 to 42] y versus 40 [IQR 32 to 51] y; p < 0.00001). Conclusions: The baseline distribution of HPV genotypes in this largely unvaccinated population indicates that the HPV9 vaccine provides good protection from high-risk HPV infections. Determining the frequency of genotypes causing abnormal cytology in this population post–vaccine implementation will be important to assess efficacy of vaccination and monitor for any potential genotype replacement.

Publisher

University of Toronto Press Inc. (UTPress)

Subject

Infectious Diseases,Microbiology (medical)

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Are blood cultures the infectious diseases faecal immunochemical test?;Journal of the Association of Medical Microbiology and Infectious Disease Canada;2023-09-18

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