Maternal allergic asthma during pregnancy alters fetal lung and immune development in sheep: potential mechanisms for programming asthma and allergy

Author:

Wooldridge Amy L.1ORCID,Clifton Vicki L.12ORCID,Moss Timothy J. M.34,Lu Hui3,Jamali Monerih5,Agostino Stefanie5,Muhlhausler Beverly S.6ORCID,Morrison Janna L.7ORCID,Matteo Robert8,Wallace Megan J.34,Bischof Robert J.35,Gatford Kathryn L.1ORCID

Affiliation:

1. Robinson Research Institute and Adelaide Medical SchoolUniversity of Adelaide Adelaide SA Australia

2. Mater Medical Research InstituteUniversity of Queensland Brisbane QLD Australia

3. The Ritchie CentreHudson Institute of Medical Research Clayton VIC Australia

4. Department of Obstetrics and GynaecologyMonash University Clayton VIC Australia

5. Department of PhysiologyMonash University Clayton VIC Australia

6. Food and Nutrition Research CentreDepartment of Food and Wine SciencesSchool of Agriculture, Food and WineThe University of Adelaide Adelaide SA Australia

7. Early Origins of Adult Health Research GroupSchool of Pharmacy and Medical SciencesUniversity of South Australia Adelaide SA Australia

8. Department of Anatomy and Developmental BiologyMonash University Clayton VIC Australia

Funder

Jack Brockhoff Foundation

Department of Industry, Innovation, Science, Research and Tertiary Education, Australian Government

Australian Research Council

Department of Health, Australian Government

National Health and Medical Research Council

Publisher

Wiley

Subject

Physiology

Reference52 articles.

1. American College of Obstetricians and Gynecologists(2017).ACOG Committee Opinion. No 713. Antenatal corticosteroid therapy for preterm maturation.https://www.acog.org/Clinical-Guidance-and-Publications/Committee-Opinions/Committee-on-Obstetric-Practice/Antenatal-Corticosteroid-Therapy-for-Fetal-Maturation.

2. Immune response to allergens in sheep sensitized to house dust mite

3. Induction of allergic inflammation in the lungs of sensitized sheep after local challenge with house dust mite

4. Uniform definition of asthma severity, control, and exacerbations: Document presented for the World Health Organization Consultation on Severe Asthma

5. CD44 is necessary for optimal contact allergic responses but is not required for normal leukocyte extravasation.

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