PHD2 inactivation in Type I cells drives HIF‐2α‐dependent multilineage hyperplasia and the formation of paraganglioma‐like carotid bodies-Reference-Cited by-同舟云学术

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PHD2 inactivation in Type I cells drives HIF‐2α‐dependent multilineage hyperplasia and the formation of paraganglioma‐like carotid bodies

Published:2018-08-19 Issue:18 Volume:596 Page:4393-4412
ISSN:0022-3751
Container-title:The Journal of Physiology
language:en
Short-container-title:J Physiol

Author:

Fielding James W.¹²,Hodson Emma J.¹,Cheng Xiaotong¹²,Ferguson David J. P.³^ORCID,Eckardt Luise¹,Adam Julie¹²,Lip Philomena¹,Maton‐Howarth Matthew¹,Ratnayaka Indrika²,Pugh Christopher W.¹,Buckler Keith J.⁴^ORCID,Ratcliffe Peter J.¹²⁵,Bishop Tammie¹^ORCID

Affiliation:

1. Target Discovery InstituteUniversity of Oxford, Oxford, UK

2. Ludwig Institute for Cancer ResearchUniversity of Oxford, Oxford, UK

3. John Radcliffe HospitalUniversity of Oxford, Oxford, UK

4. Department of Physiology, Anatomy and GeneticsUniversity of Oxford Oxford UK

5. The Francis Crick Institute London UK

Funder

Ludwig Institute for Cancer Research

Wellcome Trust

Cancer Research UK

Publisher

Wiley

Subject

Physiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1113/JP275996

Reference71 articles.

1. Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

2. Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor

3. The human carotid body at high altitudes;Arias‐Stella J;Pathol Microbiol (Basel),1973

4. Chief cell hyperplasia in the human carotid body at high altitudes: Physiologic and pathologic significance

5. A Knock-in Mouse Model of Human PHD2 Gene-associated Erythrocytosis Establishes a Haploinsufficiency Mechanism

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