Circadian rhythm of brain‐derived neurotrophic factor in serum and plasma

Author:

Ehrhardt Maren12ORCID,Schreiber Stefanie2345,Duderstadt Yves126,Braun‐Dullaeus Rüdiger1,Borucki Katrin7,Brigadski Tanja89,Müller Notger G.210,Leßmann Volkmar381112,Müller Patrick12311

Affiliation:

1. Division of Cardiology and Angiology University Hospital Magdeburg Magdeburg Germany

2. German Center for Neurodegenerative Diseases (DZNE) Magdeburg Germany

3. Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (C‐I‐R‐C) Magdeburg Germany

4. Division of Neurology University Hospital Magdeburg Magdeburg Germany

5. Department of Neurology, Medical Faculty Heinrich Heine University Düsseldorf Germany

6. Institute of Sport Science Otto‐von‐Guericke University Magdeburg Germany

7. Institute of Clinical Chemistry and Pathobiochemistry Otto‐von‐Guericke University Magdeburg Germany

8. Institute of Physiology Otto‐von‐Guericke University Magdeburg Germany

9. Department of Informatics and Microsystems Technology University of Applied Sciences Kaiserslautern Zweibrücken Germany

10. Degenerative and Chronic Diseases, Faculty of Health Sciences Brandenburg University of Potsdam Potsdam Germany

11. German Center for Mental Health (DZPG) Magdeburg Germany

12. Center for Behavioural Brain Sciences (CBBS) Magdeburg Germany

Abstract

AbstractThe neurotrophic growth factor brain‐derived neurotrophic factor (BDNF) plays a crucial role in various neurodegenerative and psychiatric diseases, such as Alzheimer's disease, schizophrenia and depression. BDNF has been proposed as a potential biomarker for diagnosis, prognosis and monitoring therapy. Understanding the factors influencing BDNF levels and whether they follow a circadian rhythm is essential for interpreting fluctuations in BDNF measurements. We aimed to investigate the circadian rhythm of BDNF by collecting multiple peripheral venous blood samples from young, healthy male participants at 12 different time points over 24 h. In addition, vital parameters, cortisol and insulin like growth factor 1 (IGF1) were measured to explore potential regulatory mechanisms, interfering variables and their correlations with BDNF concentration. The findings revealed that plasma BDNF did not exhibit any significant fluctuations over 24 h, suggesting the absence of a circadian rhythm. However, serum BDNF levels decreased during sleep. Furthermore, serum BDNF showed a positive correlation with heart rate but a negative correlation with IGF1. No significant correlation was observed between cortisol and BDNF or IGF1. Although plasma BDNF suggests steady‐state conditions, the decline of serum BDNF during the nocturnal period could be attributed to physical inactivity and associated with reduced haemodynamic blood flow (heart rate reduction during sleep). The type of sample collection (peripheral venous cannula vs. blood sampling using a butterfly system) does not significantly affect the measured BDNF levels. The sample collection during the day did not significantly affect BDNF analysis, emphasizing the importance of considering activity levels rather than timing when designing standardized protocols for BDNF assessments.

Publisher

Wiley

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