Age‐related decline in GABAergic intracortical inhibition can be counteracted by long‐term learning of balance skills

Author:

Kuhn Yves‐Alain1,Egger Sven1,Bugnon Matteo1,Lehmann Nico1234,Taubert Marco245,Taube Wolfgang1

Affiliation:

1. Department of Neurosciences and Movement Science, Faculty of Science and Medicine University of Fribourg Fribourg Switzerland

2. Department of Sport Science, Institute III, Faculty of Humanities Otto von Guericke University Magdeburg Germany

3. Department of Neurology Max Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany

4. Collaborative Research Center 1436 Neural Resources of Cognition Otto von Guericke University Magdeburg Germany

5. Center for Behavioral and Brain Science (CBBS) Otto von Guericke University, Universitätsplatz 2 Magdeburg Germany

Abstract

AbstractAgeing induces a decline in GABAergic intracortical inhibition, which seems to be associated not only with decremental changes in well‐being, sleep quality, cognition and pain management but also with impaired motor control. So far, little is known regarding whether targeted interventions can prevent the decline of intracortical inhibition in the primary motor cortex in the elderly. Therefore, the present study investigated whether age‐related cortical dis‐inhibition could be reversed after 6 months of balance learning and whether improvements in postural control correlated with the extent of reversed dis‐inhibition. The results demonstrated that intracortical inhibition can be upregulated in elderly subjects after long‐term balance learning and revealed a correlation between changes in balance performance and intracortical inhibition. This is the first study to show physical activity‐related upregulation of GABAergic inhibition in a population with chronic dis‐inhibition and may therefore be seminal for many pathologies in which the equilibrium between inhibitory and excitatory neurotransmitters is disturbed. imageKey points Ageing induces a decline in GABAergic intracortical inhibition. So far, little is known regarding whether targeted interventions can prevent the decline of intracortical inhibition in the primary motor cortex in the elderly. After 6 months of balance learning, intracortical inhibition can be upregulated in elderly subjects. The results of this study also revealed a correlation between changes in balance performance and intracortical inhibition. This is the first study to show physical activity‐related upregulation of GABAergic inhibition in a population with chronic dis‐inhibition.

Publisher

Wiley

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