1. Computational Biology, Department of Computer Science; University of Oxford; Oxford OX1 3QD UK
2. US Food and Drug Administration; 10903 New Hampshire Avenue Silver Spring MD 20993 USA
3. College of Engineering, Mathematics and Physical Science; University of Exeter; Exeter EX4 4QF UK
4. Insigneo institute for in-silico medicine and Department of Computer Science; University of Sheffield; Regent Court Sheffield S1 4DP UK