Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery

Author:

Pizzo Michelle E.12ORCID,Wolak Daniel J.12,Kumar Niyanta N.1,Brunette Eric3,Brunnquell Christina L.4,Hannocks Melanie‐Jane56,Abbott N. Joan7,Meyerand M. Elizabeth248,Sorokin Lydia56,Stanimirovic Danica B.3,Thorne Robert G.1291011

Affiliation:

1. School of Pharmacy Division of Pharmaceutical Sciences, University of Wisconsin‐Madison Madison WI USA

2. Clinical Neuroengineering Training Program University of Wisconsin‐Madison Madison WI USA

3. Human Health Therapeutics Research Centre National Research Council of Canada Ottawa Canada

4. Department of Medical Physics University of Wisconsin‐Madison Madison WI USA

5. Institute of Physiological Chemistry and Pathobiochemistry Muenster University Muenster Germany

6. Cells‐in‐Motion Cluster of Excellence Muenster University Muenster Germany

7. Institute of Pharmaceutical Science King's College London London UK

8. Department of Biomedical Engineering University of Wisconsin‐Madison Madison WI USA

9. Neuroscience Training Program University of Wisconsin‐Madison Madison WI USA

10. Cellular and Molecular Pathology Graduate Program University of Wisconsin‐Madison Madison WI USA

11. Institute for Clinical and Translational Research University of Wisconsin‐Madison WI USA

Funder

National Center for Advancing Translational Sciences

Deutsche Forschungsgemeinschaft

National Science Foundation

National Institutes of Health

Publisher

Wiley

Subject

Physiology

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