Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age‐related anabolic resistance to exercise in humans-Reference-Cited by-同舟云学术

Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age‐related anabolic resistance to exercise in humans

Published:2016-11-07 Issue:24 Volume:594 Page:7399-7417
ISSN:0022-3751
Container-title:The Journal of Physiology
language:en
Short-container-title:J Physiol

Author:

Brook Matthew S.¹,Wilkinson Daniel J.¹,Mitchell William K.¹²,Lund Jonathan N.¹²,Phillips Bethan E.¹,Szewczyk Nathaniel J.¹^ORCID,Greenhaff Paul L.¹,Smith Kenneth¹,Atherton Philip J.¹

Affiliation:

1. MRC‐ARUK Centre of Excellence for Musculoskeletal Ageing Research Clinical, Metabolic and Molecular Physiology University of Nottingham Derby UK

2. Departments of Surgery Royal Derby Hospital Derby UK

Funder

Dunhill Medical Trust

Medical Research Council

University of Nottingham

Biotechnology and Biological Sciences Research Council

Publisher

Wiley

Subject

Physiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1113/JP272857

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3. Muscle protein synthesis in response to nutrition and exercise

4. Cyclic stretch reduces myofibrillar protein synthesis despite increases in FAK and anabolic signalling in L6 cells

5. Phosphorylation of p70S6kcorrelates with increased skeletal muscle mass following resistance exercise

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