A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+current-Reference-Cited by-同舟云学术

A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+current

Published:2015-03-13 Issue:6 Volume:593 Page:1429-1442
ISSN:0022-3751
Container-title:The Journal of Physiology
language:en
Short-container-title:J Physiol

Author:

Yang Pei-Chi¹,Song Yejia²,Giles Wayne R.³,Horvath Balazs¹,Chen-Izu Ye¹,Belardinelli Luiz⁴,Rajamani Sridharan⁴,Clancy Colleen E.¹

Affiliation:

1. University of California Davis; Davis CA USA

2. Division of Cardiovascular Medicine; University of Florida; Gainesville FL 32610 USA

3. Faculty of Kinesiology; University of Calgary; Calgary AB Canada

4. Department of Biology; Cardiovascular Therapeutic Area; Gilead Sciences; Fremont CA USA

Publisher

Wiley

Subject

Physiology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1113/jphysiol.2014.279554/fullpdf

Reference48 articles.

1. Electrical heterogeneity within the ventricular wall;Antzelevitch;Basic Res Cardiol,2001

2. The role of late INa in development of cardiac arrhythmias;Antzelevitch;Handb Exp Pharmacol,2014

3. The role of fibroblasts in complex fractionated electrograms during persistent/permanent atrial fibrillation: implications for electrogram-based catheter ablation;Ashihara;Circ Res,2012

4. A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias;Belardinelli;J Pharmacol Exp Ther,2013

5. Molecular mechanism for an inherited cardiac arrhythmia;Bennett;Nature,1995

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