Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance

Author:

Federico Marilen1,Portiansky Enrique L.2,Sommese Leandro1,Alvarado Francisco J.3,Blanco Paula G.4,Zanuzzi Carolina N.2,Dedman John5,Kaetzel Marcia5,Wehrens Xander H. T.6ORCID,Mattiazzi Alicia1,Palomeque Julieta1ORCID

Affiliation:

1. Centro de Investigaciones Cardiovasculares, CCT-La Plata-CONICET; Facultad de Cs. Médicas, UNLP; La Plata Argentina

2. Laboratorio de Análisis de Imágenes; Facultad de Cs. Veterinarias, UNLP; La Plata Argentina

3. Department of Molecular and Integrative Physiology; University of Michigan; Ann Arbor MI USA

4. Servicio de Ecocardiografía; Facultad de Veterinaria, UNLP; La Plata Argentina

5. Department of Genome Science; University of Cincinnati College of Medicine; Cincinnati OH USA

6. Cardiovascular Research Institute, Departments of Molecular Physiology and Biophysics, Medicine (in Cardiology), Pediatrics; and Center for Space Medicine; Baylor College of Medicine; Houston TX USA

Funder

Consejo Nacional de Investigaciones Científicas y Técnicas

National Heart, Lung, and Blood Institute

American Heart Association

FONCyT Argentina

Publisher

Wiley

Subject

Physiology

Reference70 articles.

1. Changes in islet plasma membrane calcium-ATPase activity and isoform expression induced by insulin resistance;Alzugaray;Arch Biochem Biophys,2009

2. CaMKII in myocardial hypertrophy and heart failure;Anderson;J Mol Cell Cardiol,2011

3. Myocardial fibrosis and apoptosis, but not inflammation, are present in long-term experimental diabetes;Ares-Carrasco;Am J Physiol,2009

4. Mitochondrial fragmentation in apoptosis;Arnoult;Trends Cell Biol,2007

5. Sustained cardiomyocyte apoptosis and left ventricular remodelling after myocardial infarction in experimental diabetes;Backlund;Diabetologia,2004

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