Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1β3γ2LGABAAreceptor account for theirin vivoeffects-Reference-Cited by-同舟云学术

Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1β3γ2LGABAAreceptor account for theirin vivoeffects

Published:2015-11-14 Issue:22 Volume:593 Page:4943-4961
ISSN:0022-3751
Container-title:The Journal of Physiology
language:en
Short-container-title:J Physiol

Author:

Desai Rooma¹,Savechenkov Pavel Y.²,Zolkowska Dorota³,Ge Ri Le¹,Rogawski Michael A.³,Bruzik Karol S.²,Forman Stuart A.¹,Raines Douglas E.¹,Miller Keith W.¹⁴

Affiliation:

1. Department of Anaesthesia, Critical Care and Pain Medicine; Massachusetts General Hospital; Boston MA 02114 USA

2. Deparment of Medicinal Chemistry and Pharmacognosy; University of Illinois at Chicago; Chicago IL 60612 USA

3. Department of Neurology, School of Medicine; University of California; Davis, Sacramento CA 95817 USA

4. Department of Biological Chemistry and Molecular Pharmacology; Harvard Medical School; Boston MA 02115 USA

Publisher

Wiley

Subject

Physiology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1113/JP270971/fullpdf

Reference71 articles.

1. Kinetic properties of the pentobarbitone-gated chloride current in frog sensory neurones;Akaike;J Physiol,1987

2. Activation of GABAA receptors containing the α4 subunit by GABA and pentobarbital;Akk;J Physiol,2004

3. Activation and block of recombinant GABAA receptors by pentobarbitone: a single-channel study;Akk;Br J Pharmacol,2000

4. Anesthetic and convulsant barbiturates alter gamma-aminobutyric acid-stimulated chloride flux across brain membranes;Allan;J Pharmacol Exp Ther,1986

5. Gating-enhanced accessibility of hydrophobic sites within the transmembrane region of the nicotinic acetylcholine receptor's δ-subunit. A time-resolved photolabeling study;Arevalo;J Biol Chem,2005

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