Peroxisome proliferator-activated receptor-γ coactivator 1 α1 induces a cardiac excitation-contraction coupling phenotype without metabolic remodelling

Author:

Mutikainen Maija1,Tuomainen Tomi1,Naumenko Nikolay1,Huusko Jenni1,Smirin Boris12,Laidinen Svetlana1,Kokki Krista3,Hynynen Heidi1,Ylä-Herttuala Seppo1,Heinäniemi Merja3,Ruas Jorge L.4,Tavi Pasi1

Affiliation:

1. Department of Biotechnology and Molecular Medicine; A.I. Virtanen Institute for Molecular Sciences; University of Eastern Finland; Kuopio Finland

2. Institute of General Pathology and Pathophysiology; Moscow Russia

3. Institute of Biomedicine; School of Medicine; University of Eastern Finland; Kuopio Finland

4. Department of Physiology and Pharmacology; Karolinska Institutet; Stockholm Sweden

Funder

Suomen Akatemia

Sigrid Juselius Foundation

Sydäntutkimussäätiö

Vetenskapsrådet

Publisher

Wiley

Subject

Physiology

Reference86 articles.

1. Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle;Arany;Cell Metab,2005

2. Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-γ coactivator 1;Arany;Proc Natl Acad Sci USA,2006

3. Transcriptional network analysis in muscle reveals AP-1 as a partner of PGC-1α in the regulation of the hypoxic gene program;Baresic;Mol Cell Biol,2014

4. Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus;Barr;Gene Ther,1994

5. Glucose and fatty acid metabolism in the isolated working mouse heart;Belke;Am J Physiol,1999

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