Elevated levels of branched-chain amino acids have little effect on pancreatic islet cells, butl-arginine impairs function through activation of the endoplasmic reticulum stress response-Reference-Cited by-同舟云学术

Elevated levels of branched-chain amino acids have little effect on pancreatic islet cells, butl-arginine impairs function through activation of the endoplasmic reticulum stress response

Published:2014-02-12 Issue:3 Volume:99 Page:538-551
ISSN:0958-0670
Container-title:Experimental Physiology
language:en
Short-container-title:Experimental Physiology

Author:

Mullooly Niamh¹²,Vernon Wendy²,Smith David M.³,Newsholme Philip¹⁴

Affiliation:

1. School of Biomolecular and Biomedical Science; University College Dublin; Dublin 4 Ireland

2. AstraZeneca; Pharmacueticals R&D; Alderley Park; Macclesfield Cheshire UK

3. AstraZeneca, Pharmacueticals R&D; CVMD; Mölndal SE-431 83 Sweden

4. School of Biomedical Sciences; Curtin Health Innovation Research Institute; Curtin University; Perth Western Australia Australia

Publisher

Wiley

Subject

Physiology,Physiology (medical),Nutrition and Dietetics

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1113/expphysiol.2013.077495/fullpdf

Reference58 articles.

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3. mTORC1 activation regulates β-cell mass and proliferation by modulation of cyclin D2 synthesis and stability;Balcazar;J Biol Chem,2009

4. Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans;Corbett;Proc Natl Acad Sci U S A,1993

5. Glutamine regulates expression of key transcription factor, signal transduction, metabolic gene, and protein expression in a clonal pancreatic β-cell line;Corless;J Endocrinol,2006

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