Chronic oral rapamycin decreases adiposity, hepatic triglycerides and insulin resistance in male mice fed a diet high in sucrose and saturated fat-Reference-Cited by-同舟云学术

Chronic oral rapamycin decreases adiposity, hepatic triglycerides and insulin resistance in male mice fed a diet high in sucrose and saturated fat

Published:2018-09-13 Issue:11 Volume:103 Page:1469-1480
ISSN:0958-0670
Container-title:Experimental Physiology
language:en
Short-container-title:Exp Physiol

Author:

den Hartigh Laura J.¹²^ORCID,Goodspeed Leela¹²,Wang Shari A.¹²,Kenerson Heidi L.³,Omer Mohamed¹²,O'Brien Kevin D.²⁴,Ladiges Warren⁵,Yeung Raymond³,Subramanian Savitha¹²

Affiliation:

1. Department of Medicine; Division of Metabolism; Endocrinology and Nutrition; University of Washington; Seattle WA 98019 USA

2. Diabetes Institute; University of Washington; Seattle WA 98019 USA

3. Department of Surgery; University of Washington; Seattle WA 98019 USA

4. Division of Cardiology; University of Washington; Seattle WA 98019 USA

5. Department of Comparative Medicine; University of Washington; Seattle WA 98019 USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Physiology,Physiology (medical),Nutrition and Dietetics

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1113/EP087207/fullpdf

Reference57 articles.

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2. Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice;Anisimov;Cell Cycle,2011

3. Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system;Arrioloa Apelo;Aging Cell,2016

4. Liver-specific p70 S6 kinase depletion protects against hepatic steatosis and systemic insulin resistance;Bae;The Journal of Biological Chemistry,2012

5. Rapamycin prevents the onset of insulin-dependent diabetes mellitus (IDDM) in NOD mice;Baeder;Clinical & Experimental Immunology,1992

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