High‐intensity interval training improves cardiomyocyte contractile function and myofilament sensitivity to intracellular Ca2+ in obese rats

Author:

dos Santos Matheus Corteletti1,da Silva Daniel Sesana2,Cordeiro Jóctan Pimentel2,Domingos Lucas Furtado3,da Silva Gomes Ezio Henrique4,Nogueira Breno Valentim45,Bocalini Danilo Sales1,Lima Leopoldo Ana Paula36,Leopoldo André Soares1236ORCID

Affiliation:

1. Postgraduate Program in Physiological Sciences, Health Sciences Center Federal University of Espírito Santo Espírito Santo Vitória Brazil

2. Postgraduate Program in Physical Education, Center of Physical Education and Sports Federal University of Espírito Santo Espírito Santo Vitória Brazil

3. Postgraduate Program in Nutrition and Health, Health Sciences Center Federal University of Espírito Santo Espírito Santo Vitória Brazil

4. Postgraduate Program in Biotechnology, Health Sciences Center Federal University of Espírito Santo Espírito Santo Vitória Brazil

5. Department of Morphology, Health Sciences Center Federal University of Espírito Santo Espírito Santo Vitória Brazil

6. Department of Sports, Center of Physical Education and Sports Federal University of Espírito Santo Espírito Santo Vitória Brazil

Abstract

AbstractHigh‐intensity interval training (HIIT) has shown significant results in addressing adiposity and risk factors associated with obesity. However, there are no studies that investigate the effects of HIIT on contractility and intracellular Ca2+ handling. The purpose of this study was to explore the impact of HIIT on cardiomyocyte contractile function and intracellular Ca2+ handling in rats in which obesity was induced by a saturated high‐fat diet (HFD). Male Wistar rats were initially randomized into a standard diet and a HFD group. The experimental protocol spanned 23 weeks, comprising the induction and maintenance of obesity (15 weeks) followed by HIIT treatment (8 weeks). Performance was assessed using the maximum oxygen consumption test (). Evaluation encompassed cardiac, adipose and skeletal muscle histology, as well as contractility and intracellular Ca2+ handling. HIIT resulted in a reduction in visceral area, an increase in , and an augmentation of gastrocnemius fibre diameter in obese subjects. Additionally, HIIT led to a decrease in collagen fraction, an increase in percentage shortening, and a reduction in systolic Ca2+/percentage shortening and systolic Ca2+/maximum shortening rates. HIIT induces physiological cardiac remodelling, enhancing the contractile function of cardiomyocytes and improving myofilament sensitivity to Ca2+ in the context of obesity. This approach not only enhances cardiorespiratory and physical performance but also reduces visceral area and prevents interstitial fibrosis.

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3