Comparison of Indocyanine Green Angiography and Optical Coherence Tomography Angiography for Polypoidal Choroidal Vasculopathy

Abstract

Purpose: To assess the diagnostic value of optical coherence tomography angiography (OCTA), and the factors affecting the diagnosis of polypoidal choroidal vasculopathy (PCV) by OCTA and indocyanine green angiography (ICGA). Methods: The numbers and area of polyps, and the presence and area of a branched vascular network (BVN) as revealed by ICGA and OCTA, were retrospectively analyzed in 43 patients with active PCV. The patients were divided into two groups according to whether the number of polyps matched between the two methods: group 1, equal number of polyps revealed by ICGA and OCTA; group 2, different number of polyps revealed by ICGA and OCTA. Results: In 43 PCV patients, the total number of polyps was 1.47 ± 0.83 in ICGA and 1.07 ± 0.91 in OCTA (<i>p</i> < 0.001), and the polyp area was 0.27 ± 0.42 mm² in ICGA and 0.17 ± 0.15 mm² in OCTA (<i>p</i> = 0.023). BVN was found in 33 eyes (76.7%) by ICGA and 29 eyes (67.4%) by OCTA (<i>p</i> < 0.001). The BVN area was 3.61 ± 2.59 mm² in ICGA and 2.74 ± 2.76 mm² in OCTA (<i>p</i> = 0.002). Central retinal thickness and central choroidal thickness were significantly greater in group 2 than group 1 (<i>p</i> < 0.001, respectively). Subretinal fluid (SRF) (<i>p</i> = 0.009) and subretinal hemorrhage (SRH) (<i>p</i> = 0.005) were significantly more prevalent in group 2 than group 1. Polyp height (<i>p</i> = 0.022) and diameter (<i>p</i> = 0.042) were significantly greater in group 2 than group 1. Conclusions: OCTA is a supplementary diagnostic technique for detecting PCV. The presence of SRF and SHR, and large polyp height and diameter, were associated with the polyp detection rate of OCTA for PCV.