DIAGNOSIS OF VITAMIN B12 DEFICIENCY IN CHILDREN BY USING METHYLMALONIC ACID, HOMOCYSTEINE AND HOLOTRANSCOBALAMINE-Reference-Cited by-同舟云学术

DIAGNOSIS OF VITAMIN B12 DEFICIENCY IN CHILDREN BY USING METHYLMALONIC ACID, HOMOCYSTEINE AND HOLOTRANSCOBALAMINE

Published:2023-08-31 Issue:2 Volume:25 Page:200-206
ISSN:2148-9645
Container-title:Kırıkkale Üniversitesi Tıp Fakültesi Dergisi
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Author:

KİRKİZ Serap¹^ORCID,ARMAN BİLİR Özlem²^ORCID,AZIK Fatih Mehmet³^ORCID,SÖNMEZ Çiğdem⁴^ORCID,YARALI Hüsniye Neşe²^ORCID

Affiliation:

1. Department of Pediatric Hematology, Gazi University School of Medicine

2. Department of Pediatric Hematology and Oncology, Ankara City Hospital; Ankara-Turkey

3. Department of Pediatric Hematology, Muğla Sıtkı Koçman University School of Medicine

4. Department of Biochemistry, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

Abstract

Objective: Vitamin B12 deficiency is a common health issue in children. Though the sensivity of serum vitamin B12 measurement for the diagnosis of vitamin B12 deficiency is low, combined methylmalonic acid, homocysteine and holotranscobalamin have been reported to be more specific biomarkers in early and accurate diagnosis. In this study, we aimed to verify the diagnosis of vitamin B12 deficiency in children by measuring methylmalonic acid, homocysteine, holotranscobalamin and to determine the accuracy of them. Material and Methods: The study included 277 patients aged

Funder

This research did not receive any specific grant from funding agencies in the public,commercial, or not-for-profit sectors.

Publisher

Kirikkale Universitesi Tıp Fakultesi Dergisi

Reference22 articles.

1. Sobczyńska-Malefora A, Gorska R, Pelisser M, Ruwona P, Witchlow B, Harrington DJ. An audit of holotranscobalamin ("Active" B12) and methylmalonic acid assays for the assessment of vitamin B12 status: application in a mixed patient population. Clin Biochem. 2014;47(1-2):82-6.

2. Hogeveen M, van Beynum I, van Rooij A, Kluijtmans L, den Heijer M, Blom H. Methylmalonic acid values in healthy Dutch children. Eur J Nutr. 2008;47(1):26-31.

3. Bjørke Monsen AL, Ueland PM. Homocysteine and methylmalonic acid in diagnosis and risk assessment from infancy to adolescence. Am J Clin Nutr. 2003;78(1):7-21.

4. Monagle PT, Tauro GP. Infantile megaloblastosis secondary to maternal vitamin B12 deficiency. Clin Lab Haematol. 1997;19(1):23-5.

5. Karagöl C, Yiğit M. Evaluation of clinical and laboratory findings and diagnostic difficulties in children with vitamin B12 deficiency. Pediatric Practice and Research. 2022;10(1):1-5.