THE EVALUATION OF TERTIARY CARE CENTER HEMOGLOBIN VARIANT DATA FOR THREE YEARS PERIOD

Abstract

Objective: Hemoglobin disorders are one of the most common hereditary diseases in the world. In this study, we aimed to evaluate the hemoglobin variants detected by hemoglobin electrophoresis for a three years period in a tertiary care center. Materials and Methods: Hemoglobin variant analysis results of 4804 different variants for a three years period were evaluated retrospectively. Hemoglobin variant analysis was performed by capillary electrophoresis method on Minicap Flex Piercing analyzer (Sebia, Lisses, France). Results: One thousand and six (20.94%) of hemoglobin variants were detected in the study. The number of the patients with thalassemia trait was 1028 (21.39%) and the number of the patients with Beta thalassemia major was 44 (0.91%). In the study, the most common hemoglobin variant was found to be HbF (45.72%). The other hemoglobin variants in decreasing order were HbD, HbS, HbE, HbC and HbH. Conclusion: The place where the study was conducted is not the region where hemoglobinopathy is most commonly known in our country. However, the outcomes of the study indicated different results than expected. It should be noted that the frequency of hemoglobinopathy and the regions where it is seen frequently may change due to the migration wave that occurs due to reasons such as sociocultural, economic and war conditions.