Yenidoğanlarda Fototerapi Tedavisinin Oksidatif Stres ve İnflamatuar Yanıt Üzerine Etkisi

Abstract

Objective: A reason for oxidative stress is photodynamic reactions with phototherapy. It is thought that phototherapy changes cytokine production which leads to different effects on the immune system. The aim of this study is to investigate the effects of light-emitting diode (LED) phototherapy and conventional phototherapy on oxidative stress and inflammatory response in neonatal hyperbilirubinemia. Material and Methods: Thirty-term newborns treated with phototherapy were enrolled on the study group. The study group was divided into LED phototherapy (n=15) and conventional phototherapy (n=15) subgroups. The control group consisted of 30-term healthy newborns. Blood samples were taken before phototherapy, at the 24th hours of phototherapy and after phototherapy treatment. Bilirubin, malonaldehyde (MDA), total oxidative stress (TOS), total antioxidant capacity (TAC), TNF- α, IL-6 and IL-8 levels were evaluated between groups. Results: There were no significant differences in MDA and TAC in the conventional phototherapy group both before and after phototherapy. However, TOS levels were significantly higher during and after phototherapy than before phototherapy in the conventional phototherapy group. In the same group, IL-8 levels were significantly higher during phototherapy than after phototherapy levels. Whereas, there were no significant differences in oxidative stress and inflammatory response parameters in the LED phototherapy group. Conclusion: While conventional phototherapy increases oxidative stress and acts at some stages of the inflammatory response, there are no effects of LED phototherapy on antioxidant defence systems and inflammatory response.