Affiliation:
1. Hitit University Erol Olçok Training and Research Hospital, Clinic of Pediatrics
2. Kırıkkale University Faculty of Medicine, Department of Pediatrics Division of Neonatology
Abstract
Objective: Reference values of NT-proBNP levels in newborns may vary depending on gestational age, postnatal age and Apgar scores. However, the effect of the mode of delivery has been less investigated, and the results are contradictory. In this study, it was aimed to compare NT-proBNP levels in healthy term newborns born through vaginal delivery and cesarean (C/S) and to investigate whether delivery method had an effect on it.
Material and Methods: Healthy newborns born in our hospital and with a gestational age of ≥38 weeks were included in the study. Cases (n=56) were grouped according to delivery type. Both groups were similar in terms of gender, gestational age, body weight and Apgar scores. NT-proBNP levels, hematological parameters, LDH and CPK levels were studied in blood samples taken in the first hours after birth. The two groups were compared in terms of these parameters and it was investigated whether there was a relationship between the parameters.
Results: NT-proBNP levels were 3145 (372-7231) pg/ml in newborns born vaginally and 783 (401-6563) pg/ml in newborns born by cesarean section (p
Publisher
Kirikkale Universitesi Tıp Fakultesi Dergisi
Reference32 articles.
1. Rauh M, Koch A. Plasma N-terminal pro-B-type natriuretic peptide concentrations in a control population of infants and children. Clin. Chem. 2003;49(9):1563–4.
2. Li S, Xiao Z, Li L, Hu B, Zhou Z, Yi S, et al. Establishment of normal reference values of NT-proBNP and its application in diagnosing acute heart failure in children with severe hand foot and mouth disease. Medicine (Baltimore).2018;97(36):e12218.
3. Zigabea S, Gkiougkia E, Vrankenb L, Linthoutc CV, Seghaye MC. Early Human Development Biomarkers of neonatal stress assessment: A prospective study H. Rouatbia,Volume 137, October 2019, 104826
4. Johns MC, Stephenson C. Amino-Terminal Pro–B-Type Natriuretic Peptide Testing in Neonatal and Pediatric Patients. Am. J. Cardiol. 2008;101(3A):S76–S81.
5. Deng M, Lin C, Tang W, Zhu H, Zhang Y. Plasma N-terminal pro-B-type natriuretic peptide: Selecting the optimal heart failure marker in children of age up to 18 years. Int. J. Clin. Exp. Pathol. 2016;9(10):10756–62.