Use of Nonsteroidal Anti-Inflammatory Drugs and Incidence of Melanoma in the United States Radiologic Technologists Study

Author:

Mai Jim Z.1ORCID,Kitahara Cari M.1ORCID,Sargen Michael R.1ORCID,Little Mark P.1ORCID,Alexander Bruce H.2ORCID,Linet Martha S.1ORCID,Tucker Margaret A.1ORCID,Cahoon Elizabeth K.1ORCID

Affiliation:

1. 1Division of Cancer Epidemiology and Genetics, NCI, NIH, U.S. Department of Health and Human Services, University of Minnesota, Minneapolis, Minnesota.

2. 2Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, Minnesota.

Abstract

Abstract Although NSAIDs have been associated with both reduced and increased cutaneous melanoma risk, few studies have examined these associations by ultraviolet radiation (UVR) or personal sun-sensitivity. We examined the associations between NSAID use and first primary invasive cutaneous melanoma among 58,227 non-Hispanic white participants in the United States Radiologic Technologists cohort study. Poisson regression was used to calculate rate ratios (RR) and 95% likelihood-based confidence intervals (CI), adjusting for attained age, birth cohort, and ambient UVR. No significant association of melanoma was observed for any use of NSAIDs (RR, 0.87; 95% CI, 0.71–1.09). The relative risks of melanoma for the highest categories of aspirin and other NSAID use (≥5 times per month vs. none) were 0.93 (95% CI, 0.74–1.16) and 1.02 (95% CI, 0.83–1.25), respectively. Further analyses did not reveal dose–response for trends in frequency of NSAID use or interactions with sex, UVR, eye and hair color, and skin complexion. In this large nationwide study, NSAID use was not associated with melanoma risk. Prevention Relevance: NSAIDs have been associated with both reduced and increased melanoma risk. However, few studies have examined the role of UVR or personal sun-sensitivity on these associations. Our findings strengthen the evidence that NSAID use is not associated with melanoma risk, even in sun-sensitive subgroups.

Funder

Division of Cancer Epidemiology and Genetics, National Cancer Institute

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

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