Epitope and Fc-Mediated Cross-linking, but Not High Affinity, Are Critical for Antitumor Activity of CD137 Agonist Antibody with Reduced Liver Toxicity-Reference-Cited by-同舟云学术

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Epitope and Fc-Mediated Cross-linking, but Not High Affinity, Are Critical for Antitumor Activity of CD137 Agonist Antibody with Reduced Liver Toxicity

Published:2020-01-23 Issue:4 Volume:19 Page:1040-1051
ISSN:1535-7163
Container-title:Molecular Cancer Therapeutics
language:en
Short-container-title:Mol Cancer Ther

Author:

Ho Sun K.,Xu Zhenghai,Thakur Archana,Fox Melvin,Tan Siu Sze,DiGiammarino Enrico,Zhou Li^ORCID,Sho Mien,Cairns Belinda,Zhao Vivian,Xiong Mengli,Samayoa Josue,Forsyth Charles M.,Powers David B.,Chao Debra T.,Hollenbaugh Diane,Alvarez Hamsell M.,Akamatsu Yoshiko

Funder

AbbVie

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Cited by 31 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. NKG2D-bispecific enhances NK and CD8+ T cell antitumor immunity;Cancer Immunology, Immunotherapy;2024-08-08

2. Design of Crosslinking Antibodies For T-Cell Activation: Experimental and Computational Analysis of PD-1/CD137 Bispecific Agents;The AAPS Journal;2024-06-11

3. Increased co-expression of 4-1BB with PD-1 on CD8+ tumor-infiltrating lymphocytes is associated with improved prognosis and immunotherapy response in cervical cancer;Frontiers in Oncology;2024-05-02

4. ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1–Directed 4-1BB Activation;Cancer Research;2024-03-19

5. Fcγ receptors and immunomodulatory antibodies in cancer;Nature Reviews Cancer;2023-12-07

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