The Few yet Fabp4ulous Pancreatic Stellate Cells Give Rise to Protumoral CAFs-Reference-Cited by-同舟云学术

The Few yet Fabp4ulous Pancreatic Stellate Cells Give Rise to Protumoral CAFs

Published:2022-02-01 Issue:2 Volume:12 Page:296-298
ISSN:2159-8274
Container-title:Cancer Discovery
language:en
Short-container-title:

Author:

Cukierman Edna¹^ORCID

Affiliation:

1. Cancer Signaling and Epigenetics Program, Marvin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Temple Health, Philadelphia, Pennsylvania.

Abstract

Abstract Summary: Cancer-associated fibroblast (CAF) pro– and anti–pancreatic cancer functional dichotomy has been at the center of numerous studies. In this issue of Cancer Discovery, Helms and colleagues demonstrate that although pancreatic stellate cell–derived CAFs constitute a desmoplastic cell minority, these cells play a protumorigenic role via microenvironmental mechanomodulation. See related article by Helms et al., p. 484.

Funder

NIH NCI

Publisher

American Association for Cancer Research (AACR)

Subject

Oncology

Link

https://aacrjournals.org/cancerdiscovery/article-pdf/12/2/296/3035328/296.pdf

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