Biomolecular Condensation: A New Phase in Cancer Research-Reference-Cited by-同舟云学术

Biomolecular Condensation: A New Phase in Cancer Research

Published:2022-07-19 Issue:9 Volume:12 Page:2031-2043
ISSN:2159-8274
Container-title:Cancer Discovery
language:en
Short-container-title:

Author:

Chakravarty Anupam K.¹^ORCID,McGrail Daniel J.²^ORCID,Lozanoski Thomas M.³^ORCID,Dunn Brandon S.⁴^ORCID,Shih David J.H.⁵^ORCID,Cirillo Kara M.⁴^ORCID,Cetinkaya Sueda H.⁴,Zheng Wenjin Jim⁵^ORCID,Mills Gordon B.⁶^ORCID,Yi S. Stephen⁷⁸⁹^ORCID,Jarosz Daniel F.¹⁰¹¹^ORCID,Sahni Nidhi⁴¹²¹³^ORCID

Affiliation:

1. 1Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan.

2. 2Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, Ohio.

3. 3Department of Bioengineering, Stanford University, Stanford, California.

4. 4Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas.

5. 5School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, Texas.

6. 6Department of Cell, Developmental and Cancer Biology, Knight Cancer Institute, Oregon Health and Sciences University, Portland, Oregon.

7. 7Department of Oncology, Livestrong Cancer Institutes, The University of Texas at Austin, Austin, Texas.

8. 8Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas.

9. 9Interdisciplinary Life Sciences Graduate Programs (ILSGP) and Oden Institute for Computational Engineering and Sciences (ICES), The University of Texas at Austin, Austin, Texas.

10. 10Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California.

11. 11Department of Developmental Biology, Stanford University School of Medicine, Stanford, California.

12. 12Program in Quantitative and Computational Biosciences (QCB), Baylor College of Medicine, Houston, Texas.

13. 13Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Abstract

Abstract Multicellularity was a watershed development in evolution. However, it also meant that individual cells could escape regulatory mechanisms that restrict proliferation at a severe cost to the organism: cancer. From the standpoint of cellular organization, evolutionary complexity scales to organize different molecules within the intracellular milieu. The recent realization that many biomolecules can “phase-separate” into membraneless organelles, reorganizing cellular biochemistry in space and time, has led to an explosion of research activity in this area. In this review, we explore mechanistic connections between phase separation and cancer-associated processes and emerging examples of how these become deranged in malignancy. Significance: One of the fundamental functions of phase separation is to rapidly and dynamically respond to environmental perturbations. Importantly, these changes often lead to alterations in cancer-relevant pathways and processes. This review covers recent advances in the field, including emerging principles and mechanisms of phase separation in cancer.

Funder

Komen Foundation

National Institute of General Medical Sciences

NIH

Department of Defense

NCI

CPRIT

Research Grant

Betty Moore Foundation

Damon Runyon Cancer Research Foundation

NSF

Publisher